以NaCl颗粒为致孔剂,采用"溶液浇铸-热压成型一颗粒沥滤"方法制备多孔β-磷酸三钙(β-TCP)/聚L-乳酸(PLLA)复合骨支架材料.研究了致孔剂用量、成型压强以及成型温度对复合材料孔隙率、体积密度及力学性能的影响;讨论了复合材料的孔隙率与其力学强度之间的关系以及细胞在支架材料上的增殖情况.扫描电镜(SEM)下,观察到β-TCP/PLLA复合材料有着开口的、均匀的及相互贯通的孔隙,孔径为100μm～400μm;排液法测得复合材料的孔隙率约为55%～65%;多孔复合材料的抗压强度(～8MPa)接近松质骨的抗压强度.研究表明:致孔剂NaCl的用量为60%(质量分数)、NaCl颗粒粒径为200μm～450μm时,在6MPa成型压强及120℃成型温度下,制得的多孔复合材料的力学强度符合骨力学性能要求,并适合骨髓基质干细胞的黏附与生长.
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