为提高骨组织工程支架材料的力学性能,改善其生物活性,综合天然与合成高分子的优点,采用溶液共混相分离法制备出聚己内酯(PCL)-壳聚糖(CS)多孔支架材料,并进一步采用离心注浆法填充具有生物活性的纳米羟基磷灰石(HA)-聚乙烯醇(PVA)复合浆料,制备了n-HA-PVA/PCL-CS复合多孔支架材料,改善了PCL-CS支架材料力学性能.采用扫描电子显微镜、红外光谱、元素分析、孔隙率和抗压强度试验对材料进行了表征.结果表明,PCL-CS支架材料的内部具有蜂窝状的相互贯通的孔隙结构,孔隙率可以达到60%～80%.CS含量越大,孔隙率越大,而抗压强度越小.填充后的n-HA-PVA/PCL-CS复合多孔支架材料,孔隙率有所下降,但仍大于60%,而其弹性模量可提高至25.71MPa.
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