采用天然交联剂京尼平，结合相分离技术与冷冻干燥方法，制备不同交联度的明胶多孔支架。结果表明，支架的交联度随着京尼平浓度的增加而升高，最高可以达到65.3％；不同交联度的明胶支架微观呈相互连通的多孔结构，且孔径随交联度的升高而降低；通过调控明胶支架的交联度，可以调控支架的降解时间。
Genipin crosslinked gelatin scaffolds with different crosslinking degrees were fabricated using phase separation technique and a freeze-drying method.The results indicated the crosslinking degrees were increased to 65.3%when the concentration of genipin was 20 mg/mL.The scaffold displayed high interconnected porous micro-structure and the pore size was decreased at a low crosslinking degree.In vitro degradation test showed the degrada-tion rate was controlled by crosslinking degree of gelatin scaffold.
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