欢迎登录材料期刊网

材料期刊网

中国科学院金属研究所 科学出版社
高级检索
  1. 首页
  2. 期刊
  3. 材料导报
  4. 壳聚糖智能水凝胶在生物材料领域的应用

材料导报, 2008, 22(z1): 338-341.

壳聚糖智能水凝胶在生物材料领域的应用

王华明 1, , 卢凌彬 2, , 曹阳 3,

1.海南大学理工学院,"热带生物资源"教育部重点实验室,海口,570228;华南热带农业大学基础学院,儋州,571737

2.海南大学理工学院,"热带生物资源"教育部重点实验室,海口,570228

3.海南大学理工学院,"热带生物资源"教育部重点实验室,海口,570228

基金项目:   海南省自然科学基金(50402;80631)   海南大学校科研和教改项目(Kyjj0419)   海南省教育厅科研项目(Hjkj200512)  

关键词： 壳聚糖 , 智能水凝胶 , 制备 , 应用

Application of Chitosan Intelligent Hydrogel in Biomaterials

壳聚糖智能水凝胶对于外界微小的物理化学刺激,如温度、pH、电场等能够感知并在响应过程中有显著的溶胀行为或响应性.介绍了壳聚糖智能水凝胶的制备及其在药物控释、伤口辅料和组织工程等方面的应用,并展望了其未来.

参考文献

[1] 杨振,杨连利.水凝胶的研究进展及发展新动向[J].化工中间体,2007(01):5-10.
[2] Marguerite R .[J].Progress in Polymer Science,2006,31:603.
[3] Wang T;Turhan M;Gunasekaran S .[J].Polymer International,2004,53(07):911.
[4] 吴国杰,崔英德,廖列文,吴炜亮,贾振宇.壳聚糖/聚醚半互穿网络水凝胶的性能[J].精细化工,2005(08):565-568.
[5] 吴国杰,崔英德.壳聚糖/聚醚半互穿网络水凝胶的合成与力学性能的研究[J].功能材料,2005(09):1386-1388.
[6] 吴国杰,李金蔓,王富华,崔英德,易国斌.聚醚-壳聚糖水凝胶溶胀性能的研究[J].广东工业大学学报,2005(04):1-5.
[7] 吴国杰,吴炜亮,李金蔓,周家华,崔英德.聚乙烯醇-壳聚糖水凝胶制备与溶胀行为的研究[J].广东工业大学学报,2006(03):16-20.
[8] 吴炜亮,吴国杰,赖国柱.聚乙烯醇-壳聚糖水凝胶机械性能的研究[J].广东工业大学学报,2006(04):105-109.
[9] Mahdavinia GR;Pourjavadi A;Hosseinzadeh H;Zohuriaan MJ .Modified chitosan 4. Superabsorbent hydrogels from poly(acrylic acid-co-acrylamide) grafted chitosan with salt- and pH-responsiveness properties[J].European Polymer Journal,2004(7):1399-1407.
[10] Chen SC;Wu YC;Mi FL;Lin YH;Yu LC;Sung HW .A novel pH-sensitive hydrogel composed of N,O-carboxymethyl chitosan and alginate cross-linked by genipin for protein drug delivery[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2004(2):285-300.
[11] Jinghong M;Yajing X;Qingsong Z et al.[J].Colloid and Polymer Science,2007,285:479.
[12] Baran E T;Mano J F;Reis R L .[J].Journal of Materials Science:Materials in Medicine,2004,15(07):759.
[13] Shin MS.;Kim SI.;Kim IY.;Kim NG.;Song GG.;Kim SJ. .Characterization of hydrogels based on chitosan and copolymer of poly(dimethylsiloxane) and poly(vinyl alcohol)[J].Journal of Applied Polymer Science,2002(14):2591-2596.
[14] Kim SJ.;Lee KJ.;Kim IY.;Kim SI. .Swelling kinetics of interpenetrating polymer hydrogels composed of poly(vinyl alcohol)/chitosan[J].Journal of Macromolecular Science. Pure and Applied Chemistry,2003(5):501-510.
[15] Lee WF.;Chiang WH. .Swelling and drug-release behavior of the poly(AA-co-N-vinyl pyrrolidone)/chitosan interpenetrating polymer network hydrogels[J].Journal of Applied Polymer Science,2004(4):2135-2142.
[16] Shim J W;Kang P H;Park S E et al.[J].Hwahak Konghak,2002,13(07):648.
[17] Shi L;Yang L;Chen J et al.[J].Journal of Biomaterials Science:Polymer Edition,2004,15(04):465.
[18] 王胜,杨黎明,陈捷,孙婕,李志军,王涛.聚乙烯醇/羧甲基壳聚糖共混水凝胶的辐射合成及性能[J].化学研究,2006(01):61-64.
[19] Hong CAI,Jing ZHANG,Zheng Pu ZHANG,Yan Geng ZHANG,Bing Lin HE.The Preparation and Properties of Thermosensitive Hydrogels Based on Chitosan Grafted N-isopropylacrylamide via γ-Radiation[J].中国化学快报(英文版),2004(10):1253-1254.
[20] Cerchiara T;Luppi B;Bigueci F et al.[J].Journal of Pharmacy and Pharmaeology,2002,54(11):1453.
[21] Goycoolea F M;Heras A;Aranaz I et al.[J].Advances in Chitin Sciences,2002,6:169.
[22] Goycoolea F M;Argtielles-Monalb W M;Lizardia J et al.[J].Polymer Bulletin,2007,58:225.
[23] 陈欢欢,昝佳,林莹,蒋国强,丁富新.壳聚糖/聚乙烯醇温敏水凝胶的制备及性质研究[J].清华大学学报（自然科学版）,2006(06):843-846.
[24] Molinaro G;Leroux JC;Damas J;Adam A .Biocompatibility of thermosensitive chitosan-based hydrogels: an in vivo experimental approach to injectable biomaterials.[J].Biomaterials,2002(13):2717-2722.
[25] Mochalova A E;Nikishchenkov L V;Smtmov N N et al.[J].Polymer Science Series B:Polymer Physics,2007,49(1-2):42.
[26] 袁金芳,郭保林,张晓丽,高青雨.pH、离子强度敏感性壳聚糖水凝胶的合成及其对辅酶A的控制释放[J].功能材料,2007(01):36-39,42.
[27] 黄荣华,杜予民,陈凌云,樊李红,孙立苹.pH值对壳聚糖/羧甲基壳聚糖水凝胶溶胀行为的影响[J].武汉大学学报(理学版),2003(04):465-469.
[28] 宋鹏飞,王荣民,王云普.pH敏感性壳聚糖/聚乙烯基吡咯烷酮水凝胶的制备及其性能[J].西北师范大学学报(自然科学版),2004(01):53-55.
[29] 谢云涛,宋鹏飞,何玉凤,王荣民.pH敏感性壳聚糖/聚乙烯醇水凝胶的制备及其性能研究[J].化工新型材料,2005(12):51-53.
[30] Sun Jie;Chen Jie;Yang Liming et al.[J].Journal of Biomaterials Science:Polymer Edition,2007,18(01):35.
[31] 石艳丽,许雅菁,张高奇,马敬红,梁伯润.羧甲基壳聚糖/聚（N-异丙基丙烯酰胺）半互穿网络水凝胶的制备及溶胀性能研究[J].东华大学学报（自然科学版）,2005(06):6-10.
[32] 王胜,杨黎明,陈捷,孙婕,李志军,王涛.温度及pH敏感性聚乙烯醇/羧甲基壳聚糖水凝胶的制备与性能研究[J].化学世界,2006(03):149-152.
[33] Kim SJ.;Park SJ.;Shin MS.;Kim SI. .Characteristics of electrical responsive chitosan/polyallylamine interpenetrating polymer network hydrogel[J].Journal of Applied Polymer Science,2002(9):2290-2295.
[34] Kim SJ.;Park SJ.;Kim IY.;Shin MS.;Kim SI. .Electric stimuli responses to poly(vinyl alcohol)/chitosan interpenetrating polymer network hydrogel in NaCl solutions[J].Journal of Applied Polymer Science,2002(9):2285-2289.
[35] Kim SJ.;Shin SR.;Lee JH.;Lee SH.;Kim SI. .Electrical response characterization of chitosan/polyacrylonitrile hydrogel in NaCl solutions[J].Journal of Applied Polymer Science,2003(1):91-96.
[36] Ishihara M;Obara K;Ishizuka T et al.[J].Journal of Biomedical Materials Research Part A,2003,64A(03):551.
[37] Ishihara M;Nakamura S;Masuoka K et al.[J].Artificial Organs,2006,9:8.
[38] Li Jinjiang;Xu Zhengha .[J].Journal of Pharmaceutical Sciences,2002,91(07):1669.
[39] Kumbar SG.;Soppimath KS.;Aminabhavi TM. .Synthesis and characterization of polyacrylamide-grafted chitosan hydrogel microspheres for the controlled release of indomethacin[J].Journal of Applied Polymer Science,2003(9):1525-1536.
[40] Ruel-Gariepy E.;Leclair G.;Hildgen P.;Gupta A.;Leroux JC. .Thermosensitive chitosan-based hydrogel containing liposomes for the delivery of hydrophilic molecules[J].Journal of Controlled Release: Official Journal of the Controlled Release Society,2002(2/3):373-383.
[41] Ishihara M;Ono K;Ishizuka T et al.[J].Boei Ika Daigakko Zasshi,2001,26(04):157.
[42] Ishihara M;Nakanishi K;Ono K;Sato M;Kikuchi M;Saito Y;Yura H;Matsui T;Hattori H;Uenoyama M;Kurita A .Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process.[J].Biomaterials,2002(3):833-840.
[43] Ishihara M .[J].Trends in Glycoscience and Glycotechnology,2002,14(80):331.
[44] Obara K;Ishihara M;Ishizuka T;Fujita M;Ozeki Y;Maehara T;Saito Y;Yura H;Matsui T;Hattori H;Kikuchi M;Kurita A .Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice.[J].Biomaterials,2003(20):3437-3444.
[45] Park K R;Nho Y C .[J].Polymer(Korea),2002,26(06):792.
[46] Nho YC.;Park KR. .Preparation and properties of PVA/PVP hydrogels containing chitosan by radiation[J].Journal of Applied Polymer Science,2002(8):1787-1794.
[47] Choi E K;Kim H I;Nho Y C .[J].Polymer(Korea),2003,27(04):349.
[48] Park K R;Nho Y C .[J].Radiation Physics and Chemistry,2003,67(3-4):361.
[49] Alencar De Q A A;Ferraz H G;Abraham G A et al.[J].Journal of Biomedical Materials Research,2003,64A(01):147.
[50] Chenite A;Chaput C;Wang D et al.[J].BIOMATERIALS,2000,21:2155.
[51] Cho JH;Kim SH;Park KD;Jung MC;Yang WI;Han SW;Noh JY;Lee JW .Chondrogenic differentiation of human mesenchymal stem cells using a thermosensitive poly(N-isopropylacrylamide) and water-soluble chitosan copolymer.[J].Biomaterials,2004(26):5743-5751.
上一张 下一张
上一张 下一张
计量
  • 下载量()
  • 访问量()
作者相关
文章评分
  • 您的评分：
  • 1
    0%
  • 2
    0%
  • 3
    0%
  • 4
    0%
  • 5
    0%

版权所有©2010中国科学院金属研究所中国科技出版传媒股份有限公司

本系统由北京仁和汇智信息技术有限公司设计开发

技术支持：info@rhhz.net