真空等离子喷涂的钛涂层经 ５．０ｍｏｌ／Ｌ ＮａＯＨ溶液处理后，将其浸泡在含 Ｃａ２＋、ＨＰＯ４２－的模拟生理体液（ＦＣＳ和ＳＢＦ）中，考察涂层诱导羟基磷灰石生长过程，并评价其生物活性．用ＳＥＭ观察碱处理前后和在模拟生理体液中浸泡后钛涂层的形貌，用ＡＥＳ分析了碱处理前后钛涂层的表面成分；用ＸＲＤ、ＦＴ－ＩＲ和ＥＤＳ表征浸泡后涂层表面生长物的结构和成分；并测量了处理后钛涂层在浸泡过程中溶液中离子浓度和ｐＨ值的变化．结果表明，经处理的钛涂层在模拟生理体液中能诱导羟基磷灰石在其表面生长；在ＳＢＦ和ＦＣＳ分别形成碳酸羟基磷灰石层和含氧磷灰石的羟基磷灰石层．钛涂层的活性是由于碱处理后表面形成了网状和纤维状结构的Ｎａ－Ｔｉ－Ｏ化合物．这种化合物在模拟生理溶液中释放Ｎａ＋，吸收Ｈ＋；形成水化钛酸盐，诱导羟基磷灰石成核生长．
Vacuum plasma sprayed Ti coatings were chemically treated with 5.0mol/L NaOH at 40℃ for 24h and immersed into two kinds of simulated physiological
solutions containing Ca2+, HPO2-4 ions. The surface morphologies and compositions of Ti coating before and after alkali treatment were examined by SEM
and AES respectively. The formation layers on the Ti coating after immersion in FCS and SBF were characterized by SEM, EDS, XRD and FT-IR. The changes of ion
concentration and pH value of FCS after immersion were measured by ICP-AES and pH meter. The results obtained indicate that the fibrous and net-like surface
structure forms on the surface of porous Ti coating by treatment of NaOH solution which consists of Na，Ti and O element with the atom ratio nearly equal to that
of Na2TiO3. After immersion in simulated physiological solutions, the treated Ti coating shows apatite-forming ability and the apatite formed in FCS is oriented crystallized,
plate-like HA with trace of OCP whereas the apatite precipitated in SBF is needle-like carbonate-containing hydroxyapatite. The bioactivity of the alkali treated Ti coatings
can be explained in terms of the formation of hydrated titanate which can induced apatite nucleation and growth in FCS and SBF.
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