利用原子转移自由基聚合制备了一系列两亲性氟化ABC型三嵌段共聚物mPEG-b-PMMA-b-PFMA,并对其组成进行了分析.通过调节本体氟含量和热处理改变涂层表面组成,利用X射线光电子能谱考察了涂层表面组成与人纤维蛋白原(HFg)吸附量的关系.结果表明,表面引入含氟组分后,共聚物呈现出良好的抗蛋白质吸附性能;当共聚物中含氟单体的摩尔分数达到5.98％时,样品表面HFg吸附量最小,氮含量只有0.7％,相比于PMMA表面几乎没有吸附.增加亲水部分或含氟组分的含量,HFg吸附量增加.当涂层表面组成中亲水部分EO含量在8％～12％,含氟基团含量为10％～30％时,表面氮含量低于1.5％,对HFg的阻抗吸附效果较好.
参考文献
| [1] | Pavithra D;Doble M .Bioflim formation,bacterial adhesion and host response on polymeric implants-issues and prevention[J].Biomedical Materials,2008,3(03):299. |
| [2] | El-Refaie Kenawy;S. D. Worley;Roy Broughton .The Chemistry and Applications of Antimicrobial Polymers: A State-of-the-Art Review[J].Biomacromolecules,2007(5):1359-1384. |
| [3] | Heejae Kim;Junsang Doh;Darrell J.Irvine;Robert E.Cohen;Paula T.Hammond .Large Area Two-Dimensional B Cell Arrays for Sensing and Cell-Sorting Applications[J].Biomacromolecules,2004(3):822-827. |
| [4] | Zhang Z;Chao T;Chen SF;Jiang SY .Superlow fouling sulfobetaine and carboxybetaine polymers on glass slides[J].Langmuir: The ACS Journal of Surfaces and Colloids,2006(24):10072-10077. |
| [5] | Perrier S.;Jackson SG.;Haddleton DM.;Ameduri B.;Boutevin B. .Preparation of fluorinated copolymers by copper-mediated living radical polymerization[J].Macromolecules,2003(24):9042-9049. |
| [6] | Bhatt, S.;Pulpytel, J.;Ceccone, G.;Lisboa, P.;Rossi, F.;Kumar, V.;Arefi-Khonsari, F. .Nanostructure protein repellant amphiphilic copolymer coatings with optimized surface energy by inductively excited low pressure plasma[J].Langmuir: The ACS Journal of Surfaces and Colloids,2011(23):14570-14580. |
| [7] | Wang, Y.;Finlay, J.A.;Betts, D.E.;Merkel, T.J.;Luft, J.C.;Callow, M.E.;Callow, J.A.;Desimone, J.M. .Amphiphilic Co-networks with moisture-induced surface segregation for high-performance nonfouling coatings[J].Langmuir: The ACS Journal of Surfaces and Colloids,2011(17):10365-10369. |
| [8] | Finlay JA;Krishnan S;Callow ME;Callow JA;Dong R;Asgill N;Wong K;Kramer EJ;Ober CK .Settlement of Ulva zoospores on patterned fluorinated and PEGylated monolayer surfaces[J].Langmuir: The ACS Journal of Surfaces and Colloids,2008(2):503-510. |
| [9] | Park, D.;Weinman, C.J.;Finlay, J.A.;Fletcher, B.R.;Paik, M.Y.;Sundaram, H.S.;Dimitriou, M.D.;Sohn, K.E.;Callow, M.E.;Callow, J.A.;Handlin, D.L.;Willis, C.L.;Fischer, D.A.;Kramer, E.J.;Ober, C.K. .Amphiphilic surface active triblock copolymers with mixed hydrophobic and hydrophilic side chains for tuned marine fouling-release properties.[J].Langmuir: The ACS Journal of Surfaces and Colloids,2010(12):9772-9781. |
| [10] | Jankova K.;Kops J.;Batsberg W.;Chen XY. .Synthesis of amphiphilic PS-b-PEG-b-PS by atom transfer radical polymerization[J].Macromolecules,1998(2):538-541. |
| [11] | 何卫东.高分子化学实验[M].合肥:中国科学技术大学出版社,2003 |
| [12] | 布里格斯.聚合物表面分析[M].北京:化学工业出版社,2000 |
| [13] | Yao, Fang;Xu, LiQun;Fu, Guo-Dong;Lin, BaoPing .Sliding-Graft Interpenetrating Polymer Networks from Simultaneous “Click Chemistry” and Atom Transfer Radical Polymerization[J].Macromolecules,2010(23):9761-9770. |
| [14] | Santanu Ray;Alexander G. Shard .Quantitative Analysis of Adsorbed Proteins by X-ray Photoelectron Spectroscopy[J].Analytical chemistry,2011(22):8659-8666. |
| [15] | Salmaan H. Baxamusa .Random Copolymer Films with Molecular-Scale Compositional Heterogeneities that Interfere with Protein Adsorption[J].Advanced functional materials,2009(21):3489. |
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