{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":5,"startPagecode":1},"records":[{"abstractinfo":"用密度法分离富集了太西无烟煤<span style=\"color:red\">镜</span><span style=\"color:red\">质</span><span style=\"color:red\">组</span>、丝质<span style=\"color:red\">组</span>;以富集的太西无烟煤<span style=\"color:red\">镜</span><span style=\"color:red\">质</span><span style=\"color:red\">组</span>、丝质<span style=\"color:red\">组</span>为原料,经成型、炭化、活化等过程,制成活性炭;并研究了太西无烟煤<span style=\"color:red\">镜</span><span style=\"color:red\">质</span><span style=\"color:red\">组</span>、丝质<span style=\"color:red\">组</span>制备的活性炭性能.研究结果表明:由于显微组分成因及化学性质不同,太西无烟煤<span style=\"color:red\">镜</span><span style=\"color:red\">质</span><span style=\"color:red\">组</span>制备的活性炭性能优于丝质<span style=\"color:red\">组</span>,可制备比表面>1 600 m2/g的优质活性炭产品.","authors":[{"authorName":"张文辉","id":"0cbeaa7e-96a6-4d29-a2ed-15f00048a38a","originalAuthorName":"张文辉"},{"authorName":"李书荣","id":"40c66a70-5eb5-4893-b880-12eda7be9ca1","originalAuthorName":"李书荣"},{"authorName":"陈鹏","id":"942ab57c-b715-452b-96ce-333570fc5fa4","originalAuthorName":"陈鹏"},{"authorName":"梁大明","id":"61e15d2e-3198-43d8-a58f-9940c8987684","originalAuthorName":"梁大明"},{"authorName":"王岭","id":"9f8fcbde-accb-4c33-9730-5deb5d97da51","originalAuthorName":"王岭"}],"doi":"10.3969/j.issn.1007-8827.2000.02.013","fpage":"61","id":"d33e0be3-8a94-4e51-8fd4-2f00a559d2f3","issue":"2","journal":{"abbrevTitle":"XXTCL","coverImgSrc":"journal/img/cover/XXTCL.jpg","id":"70","issnPpub":"1007-8827","publisherId":"XXTCL","title":"新型炭材料"},"keywords":[{"id":"5ba16f3d-e2aa-459f-85fb-0da1f73ac415","keyword":"无烟煤","originalKeyword":"无烟煤"},{"id":"f3a3cc39-b605-43bc-8d7f-4eb79e7f3cad","keyword":"<span style=\"color:red\">镜</span><span style=\"color:red\">质</span><span style=\"color:red\">组</span>","originalKeyword":"镜质组"},{"id":"1ccec27b-f286-4d09-bb24-87311f276cde","keyword":"丝质<span style=\"color:red\">组</span>","originalKeyword":"丝质组"},{"id":"c0c257ba-d23e-4167-8733-7f706506a2ba","keyword":"活性炭","originalKeyword":"活性炭"}],"language":"zh","publisherId":"xxtcl200002013","title":"太西无烟煤<span style=\"color:red\">镜</span><span style=\"color:red\">质</span><span style=\"color:red\">组</span>、丝质<span style=\"color:red\">组</span>制备活性炭试验研究","volume":"15","year":"2000"},{"abstractinfo":"研究了加拿大焦煤和国内常用主焦煤的结焦性差异，有利于国内焦化企业很好地利用加拿大炼焦煤，优化配煤生产。对加拿大焦煤和国内常用焦煤进行常规煤质分析和煤岩特征分析，探寻了二者黏结性存在差异的原因，并利用40 kg小焦炉进行加拿大焦煤替代国内优质焦煤实验。研究表明：与国内主焦煤相比，加拿大焦煤的单一性较好，灰分较低，变质程度较低；加拿大焦煤的基氏流动度lgMF和奥亚膨胀度b值较低，均<span style=\"color:red\">质</span><span style=\"color:red\">镜</span><span style=\"color:red\">质</span><span style=\"color:red\">组</span>较少，且<span style=\"color:red\">镜</span><span style=\"color:red\">质</span><span style=\"color:red\">组</span>中含有较多裂纹和气孔，造成加拿大焦煤在成焦过程中熔融阶段流动性较小，膨胀压力较小；加拿大焦煤替代国内优质炼焦煤进行配煤炼焦，可以稳定焦炭质量。","authors":[{"authorName":"张代林","id":"00f9a4b1-a0c0-4995-af04-369803b66d70","originalAuthorName":"张代林"},{"authorName":"王伟","id":"374a6056-bdc9-4722-b6a3-0b13e1836fde","originalAuthorName":"王伟"},{"authorName":"王坤","id":"91342bb9-913b-4756-ad76-94d108bca623","originalAuthorName":"王坤"},{"authorName":"黄大中","id":"38f317f0-3cf1-48cf-b34a-060bfcd297f2","originalAuthorName":"黄大中"},{"authorName":"李伟锋","id":"e9682fd3-34ea-4642-8d31-bb6c7b91f51d","originalAuthorName":"李伟锋"},{"authorName":"郑明东","id":"8aae0127-a94e-4154-90a2-647b7b6fd6b6","originalAuthorName":"郑明东"}],"doi":"10.13228/j.boyuan.issn0449-749x.20130681","fpage":"8","id":"62ee8206-1db4-4e57-9fda-1d9fb2bc4241","issue":"12","journal":{"abbrevTitle":"GT","coverImgSrc":"journal/img/cover/GT.jpg","id":"27","issnPpub":"0449-749X","publisherId":"GT","title":"钢铁"},"keywords":[{"id":"843f3311-05ab-4c96-b8fe-46e79088b76b","keyword":"加拿大煤","originalKeyword":"加拿大煤"},{"id":"9b7a65a9-3b5c-4a96-9ac7-33deb56da929","keyword":"黏结性","originalKeyword":"黏结性"},{"id":"edfda1ba-bef7-4119-a2e8-a5083965c9da","keyword":"煤岩","originalKeyword":"煤岩"},{"id":"478d9e18-485e-415e-b37e-88e698b8c24b","keyword":"<span style=\"color:red\">镜</span><span style=\"color:red\">质</span><span style=\"color:red\">组</span>","originalKeyword":"镜质组"},{"id":"89171998-1881-41ea-8af2-c802277d899a","keyword":"小焦炉实验","originalKeyword":"小焦炉实验"}],"language":"zh","publisherId":"gt201412002","title":"加拿大焦煤和国内几种常用焦煤的结焦性差异","volume":"","year":"2014"},{"abstractinfo":"脂<span style=\"color:red\">质</span><span style=\"color:red\">组</span>学的研究属于生命科学的范畴，与人类的健康密切相关。目前，脂<span style=\"color:red\">质</span><span style=\"color:red\">组</span>学已成为代谢<span style=\"color:red\">组</span>学最重要的分支之一，且是一个非常活跃的研究领域，尤其在研究疾病方面的重要性已经引起了科学界的广泛关注。该文简要介绍了脂<span style=\"color:red\">质</span><span style=\"color:red\">组</span>学的研究内容，重点评述了脂<span style=\"color:red\">质</span><span style=\"color:red\">组</span>学分析方法，包括样品处理、轮廓分析、目标分析、成像分析以及数据处理。最后提出了脂<span style=\"color:red\">质</span><span style=\"color:red\">组</span>学分析技术和方法的展望。","authors":[{"authorName":"刘虎威","id":"26f3a2f9-a1a7-41c3-8d82-513cfb4e7793","originalAuthorName":"刘虎威"},{"authorName":"白玉","id":"e3066290-000a-452a-b969-a649a568ff9a","originalAuthorName":"白玉"}],"doi":"10.3724/SP.J.1123.2016.08006","fpage":"86","id":"0baa7646-a3d0-4cae-b8bc-9c9e165a8a1d","issue":"1","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"798a543e-0244-4771-b864-aee98c03fb58","keyword":"脂<span style=\"color:red\">质</span><span style=\"color:red\">组</span>学","originalKeyword":"脂质组学"},{"id":"5a3d56df-8bfe-4696-9653-c07bc000734f","keyword":"样品处理","originalKeyword":"样品处理"},{"id":"1a670ded-69ec-4694-8219-53bc3f7df6df","keyword":"轮廓分析","originalKeyword":"轮廓分析"},{"id":"237ecb3c-5451-435d-aa2a-5a2653a9d3eb","keyword":"目标分析","originalKeyword":"目标分析"},{"id":"d2f10254-938c-456c-8e6c-bb66707857f4","keyword":"成像分析","originalKeyword":"成像分析"},{"id":"6cb57bac-ed5b-4f7a-8e29-ba5f47b4db10","keyword":"数据处理","originalKeyword":"数据处理"},{"id":"62cfad22-16e6-4cbf-b7c2-c42f055c5a96","keyword":"综述","originalKeyword":"综述"}],"language":"zh","publisherId":"sp201701014","title":"脂<span style=\"color:red\">质</span><span style=\"color:red\">组</span>学及其分析方法","volume":"35","year":"2017"},{"abstractinfo":"代谢<span style=\"color:red\">组</span>学是对生物体受外部刺激所产生的小分子代谢产物的变化或其随时间的变化进行研究的一门学科,以实现对体液、细胞以及组织提取物等复杂的生物样本中所有代谢产物的定性和定量分析为研究目标.色谱-<span style=\"color:red\">质</span>谱联用技术在代谢<span style=\"color:red\">组</span>学的研究中已显示出极大的发展潜力.本文主要综述近年来代谢<span style=\"color:red\">组</span>学研究中涉及的色谱-<span style=\"color:red\">质</span>谱联用技术及其数据处理方法,重点介绍各种分离技术的特点及其在应用中的关键问题,并对其在代谢<span style=\"color:red\">组</span>学应用中的未来发展给予展望.","authors":[{"authorName":"黄强","id":"67807f9a-bdd0-4f3c-8b04-534681b95cc3","originalAuthorName":"黄强"},{"authorName":"尹沛源","id":"4c44a38f-f404-4822-8fd6-cd88b8461264","originalAuthorName":"尹沛源"},{"authorName":"路鑫","id":"47944854-c319-465f-b126-10bb993fb2b7","originalAuthorName":"路鑫"},{"authorName":"孔宏伟","id":"b6ae1730-4cfe-4adf-96c5-04e3dd6083cc","originalAuthorName":"孔宏伟"},{"authorName":"许国旺","id":"0ac0363e-5e61-4988-abed-ad7ae22971ff","originalAuthorName":"许国旺"}],"doi":"10.3321/j.issn:1000-8713.2009.05.007","fpage":"566","id":"80d02cd5-19e8-4953-a5df-1f263e8b84e8","issue":"5","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"723fa87d-ad1f-4b69-bf0d-31a1de4b7fc5","keyword":"色谱","originalKeyword":"色谱"},{"id":"569a440d-aac0-4625-b989-ab794f5bc002","keyword":"<span style=\"color:red\">质</span>谱","originalKeyword":"质谱"},{"id":"ba2c823c-74fa-452d-8b71-7903845ab856","keyword":"代谢<span style=\"color:red\">组</span>学","originalKeyword":"代谢组学"},{"id":"da59b072-c3e2-4a1b-947e-baf9cc40026b","keyword":"代谢谱","originalKeyword":"代谢谱"}],"language":"zh","publisherId":"sp200905007","title":"色谱-<span style=\"color:red\">质</span>谱联用技术在代谢<span style=\"color:red\">组</span>学中的应用","volume":"27","year":"2009"},{"abstractinfo":"利用原子力显微<span style=\"color:red\">镜</span>研究了浓度分别为0.01 mg/mL、0.1 mg/mL、1 mg/mL的透明<span style=\"color:red\">质</span>酸(HA)在云母上的自组装形貌,从中得出透明<span style=\"color:red\">质</span>酸在云母表面生长聚集形成树枝状分形结构是有浓度限制的结论,并对其生长聚集形成树枝状分形结构的作用机理和生长过程进行了研究.透明<span style=\"color:red\">质</span>酸的树枝状分形结构具有统计意义上的自相似性,属不规则分形结构,与计算机模拟的DLA模型相一致.研究透明<span style=\"color:red\">质</span>酸的分形结构为研究透明<span style=\"color:red\">质</span>酸各种存在状态与其生物功能之间的关系提供了有益的帮助.","authors":[{"authorName":"王书红","id":"2e18d8de-7f6f-49b4-9f3a-34140d29eb4d","originalAuthorName":"王书红"},{"authorName":"马豫峰","id":"da1324fa-da82-4ce1-8a5c-6fff9d5726de","originalAuthorName":"马豫峰"},{"authorName":"蔡继业","id":"8bf04349-2920-4313-97bd-d847f3f48166","originalAuthorName":"蔡继业"}],"doi":"","fpage":"211","id":"a374c0c9-c0f8-4191-8489-c15fd0a547a8","issue":"3","journal":{"abbrevTitle":"GFZCLKXYGC","coverImgSrc":"journal/img/cover/GFZCLKXYGC.jpg","id":"31","issnPpub":"1000-7555","publisherId":"GFZCLKXYGC","title":"高分子材料科学与工程"},"keywords":[{"id":"aa2883cb-1134-478b-92d5-cd7ebada4d58","keyword":"原子力显微<span style=\"color:red\">镜</span>","originalKeyword":"原子力显微镜"},{"id":"9b5e908c-a2b6-4f60-9aea-576e8e847dc9","keyword":"透明<span style=\"color:red\">质</span>酸","originalKeyword":"透明质酸"},{"id":"3e419bac-9362-4cf0-a741-bf5b1df8a06c","keyword":"分形","originalKeyword":"分形"}],"language":"zh","publisherId":"gfzclkxygc200703052","title":"原子力显微<span style=\"color:red\">镜</span>对透明<span style=\"color:red\">质</span>酸分形结构的研究","volume":"23","year":"2007"},{"abstractinfo":"随着原油重<span style=\"color:red\">质</span>化、劣质化程度的加深以及环境保护对燃油清洁性要求的日趋严格，对石油组成进行分子水平详细表征具有重大的现实意义和经济价值。依赖于高分辨<span style=\"color:red\">质</span>谱技术平台的石油<span style=\"color:red\">组</span>学分析技术成为实现这一目标的有力工具。本文以高分辨<span style=\"color:red\">质</span>谱技术平台为切入点，对石油<span style=\"color:red\">组</span>学定性定量分析技术的最新进展进行回顾和总结，并对其发展前景进行展望。","authors":[{"authorName":"宋春侠","id":"27f1a071-d9bf-4c8c-9c47-9222cada0427","originalAuthorName":"宋春侠"},{"authorName":"刘颖荣","id":"6f0f3ccb-22db-4b40-983f-5edc9c55dc91","originalAuthorName":"刘颖荣"},{"authorName":"刘泽龙","id":"2ff7078b-a1bc-4c5e-b13c-fe59dbc32cba","originalAuthorName":"刘泽龙"},{"authorName":"王威","id":"a6a3e649-ee93-48a0-8930-e9711e75e4fe","originalAuthorName":"王威"},{"authorName":"田松柏","id":"325c4d22-6135-4f1a-9c2a-a352bb1e45b8","originalAuthorName":"田松柏"}],"doi":"10.3724/SP.J.1123.2015.01016","fpage":"488","id":"474c97b2-0a0e-411d-ad04-f806ce7330d3","issue":"5","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"1b4cbe66-4676-4af7-a255-c8311ed20192","keyword":"<span style=\"color:red\">质</span>谱","originalKeyword":"质谱"},{"id":"9d6a230b-8825-44f0-9899-5bb75b636ee9","keyword":"分子组成","originalKeyword":"分子组成"},{"id":"14670050-d2a9-4288-9311-86cbd6d9dbc3","keyword":"石油<span style=\"color:red\">组</span>学","originalKeyword":"石油组学"},{"id":"b9df3d39-d161-4082-b9ec-571fb104b4df","keyword":"石油","originalKeyword":"石油"}],"language":"zh","publisherId":"sp201505008","title":"基于高分辨<span style=\"color:red\">质</span>谱的石油<span style=\"color:red\">组</span>学分析技术的研究进展","volume":"","year":"2015"},{"abstractinfo":"通过高效液相色谱-四极杆飞行时间质谱(HPLC-Q-TOF/MS)分别对肺癌细胞与正常细胞的极性与非极性代谢物进行指纹图谱分析,进一步应用偏最小二乘判别分析(PLS-DA)对代谢<span style=\"color:red\">组</span>学数据进行多维统计分析.研究结果显示,与正常细胞相比,肿瘤细胞存在异常的蛋白质、脂肪酸、磷脂代谢,并发现31种对分类有显著贡献的代谢小分子物质.通过本研究,建立了基于液相色谱-<span style=\"color:red\">质</span>谱联用技术的肺癌细胞代谢<span style=\"color:red\">组</span>学分析方法,发现了肺癌潜在疾病标记物,可为肺癌分子标记物的发现及其早期诊断提供新思路和新方法.","authors":[{"authorName":"余欣尉","id":"d2f390a7-ee86-4b5f-87c0-30b1c0eb9645","originalAuthorName":"余欣尉"},{"authorName":"吴谦","id":"8b9a14e5-6e24-4347-ab43-c1e942ff5ed8","originalAuthorName":"吴谦"},{"authorName":"吕望","id":"c8a0bbb5-5c5f-468e-95bf-890c1c4ca2af","originalAuthorName":"吕望"},{"authorName":"王彦","id":"b0bbc40e-d45f-4a7f-8393-e400ce5ff757","originalAuthorName":"王彦"},{"authorName":"马小琼","id":"04d6582e-acb9-49b6-b5ac-4d601cd9110c","originalAuthorName":"马小琼"},{"authorName":"陈喆","id":"92690645-7d09-413e-afd1-28dc1697771f","originalAuthorName":"陈喆"},{"authorName":"阎超","id":"2913f8d0-d913-4adf-bb91-610b7e3bf2ed","originalAuthorName":"阎超"}],"doi":"10.3724/SP.J.1123.2012.12039","fpage":"691","id":"f690cb02-efe2-4975-8127-514babdbc40b","issue":"7","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"289215ca-0763-4ced-97e0-68b2c25375f8","keyword":"高效液相色谱-四极杆飞行时间质谱","originalKeyword":"高效液相色谱-四极杆飞行时间质谱"},{"id":"ab084e7c-18cc-4184-b878-808526c6d280","keyword":"偏最小二乘判别分析","originalKeyword":"偏最小二乘判别分析"},{"id":"37de153d-faa8-4fb9-93c1-4208d416dd4c","keyword":"代谢<span style=\"color:red\">组</span>学","originalKeyword":"代谢组学"},{"id":"ce0a2df6-cd56-4c69-af74-9903f058f57b","keyword":"肺癌","originalKeyword":"肺癌"}],"language":"zh","publisherId":"sp201307014","title":"基于液相色谱-<span style=\"color:red\">质</span>谱联用技术的肺癌细胞代谢<span style=\"color:red\">组</span>学分析","volume":"31","year":"2013"},{"abstractinfo":"定量蛋白质<span style=\"color:red\">组</span>学已经成为蛋白质<span style=\"color:red\">组</span>学的一个重要分支,以生物质谱为核心的定量蛋白质组方法日益发展.按照定量所依据的<span style=\"color:red\">质</span>谱信号来源于一级<span style=\"color:red\">质</span>谱谱图还是多级<span style=\"color:red\">质</span>谱谱图可以将定量蛋白质组方法分为一级<span style=\"color:red\">质</span>谱定量和多级<span style=\"color:red\">质</span>谱定量.本文主要综述基于多级<span style=\"color:red\">质</span>谱的定量方法和技术进展,分析比较了这些方法的优缺点,并对基于多级<span style=\"color:red\">质</span>谱的定量方法发展进行了展望.","authors":[{"authorName":"张莹","id":"e5b3cc58-64d0-453f-90b0-7517866b649e","originalAuthorName":"张莹"},{"authorName":"杨芃原","id":"4ff5380d-1390-455f-beb7-cd9e03179945","originalAuthorName":"杨芃原"},{"authorName":"陆豪杰","id":"7f1303da-5ba4-4e49-8674-5d4ae4ef4e01","originalAuthorName":"陆豪杰"}],"doi":"10.3724/SP.J.1123.2013.03056","fpage":"503","id":"69ab460a-f63d-4aff-ad03-1be3501e2ad2","issue":"6","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"1588b12e-6822-4b7d-8ac4-36a88438200f","keyword":"蛋白质<span style=\"color:red\">组</span>学","originalKeyword":"蛋白质组学"},{"id":"87081978-9b0a-4fe8-bfc1-10edf8414d8f","keyword":"<span style=\"color:red\">质</span>谱","originalKeyword":"质谱"},{"id":"0ee1f34f-0045-4e38-b3f7-052203340934","keyword":"定量","originalKeyword":"定量"},{"id":"6af0e0ad-3120-459e-b9ab-2ec9c1b60659","keyword":"综述","originalKeyword":"综述"}],"language":"zh","publisherId":"sp201306002","title":"基于多级<span style=\"color:red\">质</span>谱的蛋白质<span style=\"color:red\">组</span>定量新方法新技术进展","volume":"31","year":"2013"},{"abstractinfo":"以气体致孔法制备壳聚糖(Chi)-海藻酸(Alg)聚电解<span style=\"color:red\">质</span>复合膜.用激光共聚焦扫描显微<span style=\"color:red\">镜</span>(LCSM)观测并分析复合膜的形态结构.结果表明,LCSM无需样品处理即可原位观察Chi-Alg聚电解<span style=\"color:red\">质</span>复合膜在不同层面上的内部形态结构,通过调整添加剂NaHCO3的用量可以得到平均孔径分布在30～165 μm的复合膜.该聚电解<span style=\"color:red\">质</span>复合膜作为一种潜在的生物医用材料,有望与细胞、药物及活性因子结合,在组织工程皮肤领域得到应用.","authors":[{"authorName":"马莉华","id":"d8378ad8-f855-4a0b-9a38-1c9e556b87da","originalAuthorName":"马莉华"},{"authorName":"于炜婷","id":"961e38d8-21cc-4840-8231-82ee18532ff6","originalAuthorName":"于炜婷"},{"authorName":"马小军","id":"738ca864-5418-4673-aea7-adc2ae7ffb4a","originalAuthorName":"马小军"}],"doi":"10.3969/j.issn.1007-8924.2005.02.007","fpage":"30","id":"54937480-cd17-44fe-bdbe-51a9930c601c","issue":"2","journal":{"abbrevTitle":"MKXYJS","coverImgSrc":"journal/img/cover/MKXYJS.jpg","id":"54","issnPpub":"1007-8924","publisherId":"MKXYJS","title":"膜科学与技术   "},"keywords":[{"id":"cecfbd31-22a4-4141-b41c-5f293fbdc59e","keyword":"气体致孔法","originalKeyword":"气体致孔法"},{"id":"c35135e5-5ac2-44fb-bc0d-0dcda5d9be28","keyword":"壳聚糖","originalKeyword":"壳聚糖"},{"id":"6fe83b66-5486-49bc-9574-71748a3aac76","keyword":"海藻酸","originalKeyword":"海藻酸"},{"id":"91fa14bc-9858-46e0-82e9-363fa9389f4a","keyword":"激光共聚焦扫描显微<span style=\"color:red\">镜</span>(LCSM)","originalKeyword":"激光共聚焦扫描显微镜(LCSM)"}],"language":"zh","publisherId":"mkxyjs200502007","title":"壳聚糖-海藻酸聚电解<span style=\"color:red\">质</span>复合膜 (Ⅰ)激光共聚焦扫描显微<span style=\"color:red\">镜</span>分析形貌","volume":"25","year":"2005"},{"abstractinfo":"基于液相色谱-<span style=\"color:red\">质</span>谱联用的代谢<span style=\"color:red\">组</span>学技术因其高效分离能力和高灵敏检测能力已成为生命科学研究的重要手段，但由于缺乏有效的通用标准谱图库，检测到的大量代谢物的结构难以鉴定。这制约了代谢<span style=\"color:red\">组</span>学覆盖度的提高和生物标志物的发现，造成化学和生物信息的严重丢失，成为代谢<span style=\"color:red\">组</span>学发展的主要技术瓶颈。随着质谱仪器及计算机技术的进步，基于大气压电离<span style=\"color:red\">质</span>谱（ API-MS）的代谢物结构鉴定技术飞速发展，本文从质谱仪器、代谢物分子结构式判别、数据库及谱图检索以及计算机辅助谱图解析等方面，对代谢物结构鉴定的最新进展进行了综述。","authors":[{"authorName":"孔宏伟","id":"a2b7ad1a-b788-408a-9388-7235fa2b99cd","originalAuthorName":"孔宏伟"},{"authorName":"戴伟东","id":"0b366ee5-fbf7-4265-923c-d33f2c0de1d6","originalAuthorName":"戴伟东"},{"authorName":"许国旺","id":"62ae696d-782d-4349-8a7a-9779c04acf8d","originalAuthorName":"许国旺"}],"doi":"10.3724/SP.J.1123.2014.05017","fpage":"1052","id":"d5aac405-f0fb-4466-b058-f30035b3de3b","issue":"10","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"c82e7328-e6a4-4a9b-9ed2-89a29fdcbdf0","keyword":"代谢<span style=\"color:red\">组</span>学","originalKeyword":"代谢组学"},{"id":"30f4f93e-762b-4e3e-96d0-91aca0624bf8","keyword":"液相色谱-<span style=\"color:red\">质</span>谱联用","originalKeyword":"液相色谱-质谱联用"},{"id":"955bf766-c0f7-4f9f-b21a-bc13ddcaf3c8","keyword":"大气压电离<span style=\"color:red\">质</span>谱","originalKeyword":"大气压电离质谱"},{"id":"83cba37d-45a1-42fa-9159-6a4d058ac728","keyword":"鉴定","originalKeyword":"鉴定"},{"id":"8ccd3378-063d-46a1-8d37-a0cd1d227f19","keyword":"综述","originalKeyword":"综述"}],"language":"zh","publisherId":"sp201410007","title":"基于液相色谱-<span style=\"color:red\">质</span>谱联用的代谢<span style=\"color:red\">组</span>学研究中代谢物的结构鉴定进展","volume":"","year":"2014"}],"totalpage":2342,"totalrecord":23411}