{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":5,"startPagecode":1},"records":[{"abstractinfo":"主要对多孔β-TCP生物陶瓷在体内对新<span style=\"color:red\">骨</span>生成的诱导性进行研究.首先,人为造成兔股骨髁部骨腔洞,建立<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>模型,将自制β-TCP多孔陶瓷植入,然后逐月取一系列处死、取材,并综合运用扫描电镜观察(SEM)、电子探针X显微分析(EPMA)、甲苯胺蓝染色(toluidine blue staining,TBS)和四环素双标记法(tetracycline double labeling,TDL)等测试手段,对材料植入区进行研究,试图探明β-TCP多孔陶瓷<span style=\"color:red\">修复</span><span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>时的成<span style=\"color:red\">骨</span>过程.","authors":[{"authorName":"方芳","id":"a5dc28d7-9e6c-4a06-a3ec-3a6198eedb55","originalAuthorName":"方芳"},{"authorName":"闫玉华","id":"f02c95f2-6d63-4b1f-9790-c11774c35e2d","originalAuthorName":"闫玉华"}],"doi":"","fpage":"2391","id":"41ec9214-aef4-49b4-bdc1-2ceb0285db05","issue":"z1","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"60686540-5559-42c3-8d55-e2d0ae01607f","keyword":"多孔β-TCP生物陶瓷","originalKeyword":"多孔β-TCP生物陶瓷"},{"id":"296a20ea-c090-4cbf-b738-a838c8cbfe96","keyword":"<span style=\"color:red\">修复</span><span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>","originalKeyword":"修复骨缺损"},{"id":"4debe645-62ba-4f59-8205-5fcd7a0a7cef","keyword":"成<span style=\"color:red\">骨</span>过程","originalKeyword":"成骨过程"}],"language":"zh","publisherId":"gncl2004z1667","title":"多孔β-TCP生物陶瓷成<span style=\"color:red\">骨</span>过程的研究","volume":"35","year":"2004"},{"abstractinfo":"观察胶原基纳米<span style=\"color:red\">骨</span>(nHAC)复合rhBMP-2及钛膜<span style=\"color:red\">修复</span>犬下颌<span style=\"color:red\">骨</span>拔牙创即刻钛种植体周围<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>的效果.其实验结果表明:①单纯nHAC组:术后6周已有新生<span style=\"color:red\">骨</span>小梁形成,术后12周<span style=\"color:red\">修复</span><span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>,钛种植体边缘可见较多新<span style=\"color:red\">骨</span>形成;②联合钛膜组:术后6周即见新生<span style=\"color:red\">骨</span>小梁沿钛膜生长,至术后12周,钛膜下骨密度更高,牙槽嵴顶较丰满;③复合rhBMP-2组:成<span style=\"color:red\">骨</span>过程较早,术后6周即有较多新生<span style=\"color:red\">骨</span>组织出现,术后12周新<span style=\"color:red\">骨</span>组织与宿主<span style=\"color:red\">骨</span>完全融合,并与种植体表面形成广泛的<span style=\"color:red\">骨</span>性结合.因此,nHAC具有良好的<span style=\"color:red\">骨</span>引导作用,可良好地<span style=\"color:red\">修复</span>种植体周<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>,复合rhBMP-2或/和钛膜后效果更佳.","authors":[{"authorName":"刘冰","id":"2473a021-2e3f-4aea-b376-b9ccc56314c7","originalAuthorName":"刘冰"},{"authorName":"陈鹏","id":"b4801213-fe83-48d1-bce0-3a20deaf2288","originalAuthorName":"陈鹏"},{"authorName":"王忠义","id":"d782c157-2902-4327-b9e0-c85f6617c0bd","originalAuthorName":"王忠义"},{"authorName":"岳进","id":"7e93fe5c-3212-49e1-9903-cf15f33e0f12","originalAuthorName":"岳进"},{"authorName":"毛天球","id":"98d1b8a0-4134-4946-bc17-089a943243d7","originalAuthorName":"毛天球"}],"doi":"","fpage":"331","id":"9bfe0c19-86fe-4f8e-9163-fe97f235330e","issue":"z1","journal":{"abbrevTitle":"XYJSCLYGC","coverImgSrc":"journal/img/cover/XYJSCLYGC.jpg","id":"69","issnPpub":"1002-185X","publisherId":"XYJSCLYGC","title":"稀有金属材料与工程"},"keywords":[{"id":"cc3e7ce8-e02a-4a2f-8ab0-1244cca10c4b","keyword":"胶原基纳米<span style=\"color:red\">骨</span>","originalKeyword":"胶原基纳米骨"},{"id":"13a8ba90-2e07-4ab2-830b-7e20a66139b6","keyword":"重组人<span style=\"color:red\">骨</span>形成蛋白-2","originalKeyword":"重组人骨形成蛋白-2"},{"id":"e5956c30-4eb5-4ace-9c6d-36ada191ceca","keyword":"钛膜","originalKeyword":"钛膜"},{"id":"cee23b31-afd2-4024-8570-bd2a498f9181","keyword":"种植体","originalKeyword":"种植体"},{"id":"4c37c599-415c-4929-a97f-19bb3689878d","keyword":"<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>","originalKeyword":"骨缺损"}],"language":"zh","publisherId":"xyjsclygc2006z1081","title":"胶原基纳米<span style=\"color:red\">骨</span>复合rhBMP-2及钛膜<span style=\"color:red\">修复</span>即刻钛种植体周围<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>","volume":"35","year":"2006"},{"abstractinfo":"观察胶原基纳米<span style=\"color:red\">骨</span>(nHAC)复合rhBMP-2及钛膜<span style=\"color:red\">修复</span>犬下颌<span style=\"color:red\">骨</span>拔牙创即刻钛种植体周围<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>的效果.其实验结果表明:①单纯nHAC组:术后6周已有新生<span style=\"color:red\">骨</span>小梁形成,术后12周<span style=\"color:red\">修复</span><span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>,钛种植体边缘可见较多新<span style=\"color:red\">骨</span>形成;②联合钛膜组:术后6周即见新生<span style=\"color:red\">骨</span>小梁沿钛膜生长,至术后12周,钛膜下骨密度更高,牙槽嵴顶较丰满;③复合rhBMP-2组:成<span style=\"color:red\">骨</span>过程较早,术后6周即有较多新生<span style=\"color:red\">骨</span>组织出现,术后12周新<span style=\"color:red\">骨</span>组织与宿主<span style=\"color:red\">骨</span>完全融合,并与种植体表面形成广泛的<span style=\"color:red\">骨</span>性结合.因此,nHAC具有良好的<span style=\"color:red\">骨</span>引导作用,可良好地<span style=\"color:red\">修复</span>种植体周<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>,复合rhBMP-2或/和钛膜后效果更佳.","authors":[{"authorName":"刘冰","id":"de6cc060-29b9-4c1b-a2f5-76595c59e83e","originalAuthorName":"刘冰"},{"authorName":"陈鹏","id":"e1917db2-a5e1-48d1-a2d9-8cf2f627feb7","originalAuthorName":"陈鹏"},{"authorName":"王忠义","id":"ce9a3036-8cb6-4fe8-8a24-08eeee356e7a","originalAuthorName":"王忠义"},{"authorName":"岳进","id":"173e5007-100e-4a12-901e-6025fa673dad","originalAuthorName":"岳进"},{"authorName":"毛天球","id":"f447c126-090b-4e5b-8b73-e96ebd9606f7","originalAuthorName":"毛天球"}],"doi":"","fpage":"331","id":"ba9be978-3af9-4844-986d-09ee1c28bab6","issue":"z2","journal":{"abbrevTitle":"XYJSCLYGC","coverImgSrc":"journal/img/cover/XYJSCLYGC.jpg","id":"69","issnPpub":"1002-185X","publisherId":"XYJSCLYGC","title":"稀有金属材料与工程"},"keywords":[{"id":"f96d284a-d0ac-4c52-8222-6ca2e47f47a7","keyword":"胶原基纳米<span style=\"color:red\">骨</span>","originalKeyword":"胶原基纳米骨"},{"id":"4439fc69-34a9-4005-832a-99f3d99cf50c","keyword":"重组人<span style=\"color:red\">骨</span>形成蛋白-2","originalKeyword":"重组人骨形成蛋白-2"},{"id":"532a56ba-c7ec-4203-9684-523f15e85135","keyword":"钛膜","originalKeyword":"钛膜"},{"id":"50721b35-dffb-41c0-b450-b80b3c5b94f9","keyword":"种植体","originalKeyword":"种植体"},{"id":"02332c34-dcbd-4770-8254-11450d0073e8","keyword":"<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>","originalKeyword":"骨缺损"}],"language":"zh","publisherId":"xyjsclygc2006z2081","title":"胶原基纳米<span style=\"color:red\">骨</span>复合rhBMP-2及钛膜<span style=\"color:red\">修复</span>即刻钛种植体周围<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>","volume":"35","year":"2006"},{"abstractinfo":"通过采用结构可控的多孔磷酸钙<span style=\"color:red\">骨</span>水泥(calcium acid phosphate cement,CPC)和钛合金支架材料<span style=\"color:red\">修复</span>兔颅骨<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>,比较了两种<span style=\"color:red\">修复</span>材料<span style=\"color:red\">骨</span>环境下的成<span style=\"color:red\">骨</span>性能.结果显示,与多孔钛合金材料相比,多孔CPC材料表现出了更好的成<span style=\"color:red\">骨</span>活性.CPC 材料的新生<span style=\"color:red\">骨</span>量、成<span style=\"color:red\">骨</span>速率均高于钛合金材料.而且<span style=\"color:red\">骨</span>吸收重建过程也早于钛合金材料.同时,三维贯通的孔隙结构有利于<span style=\"color:red\">骨</span>组织的长入,能够在一定程度上克服钛合金材料的应力屏蔽缺陷,使植入体在早期获得良好的固位,从而使界面<span style=\"color:red\">骨</span>性结合得以顺利进行.","authors":[{"authorName":"白峰","id":"8951f428-0fe1-42e9-a730-652b0499d1ae","originalAuthorName":"白峰"},{"authorName":"李国臣","id":"71c23630-2a12-4bb2-af80-11048ca47f5c","originalAuthorName":"李国臣"},{"authorName":"刘建","id":"80943672-0520-452c-8eae-36717fc2dbe1","originalAuthorName":"刘建"},{"authorName":"王林","id":"3a4ff501-db36-4c8a-b2a7-088c6afeca0e","originalAuthorName":"王林"},{"authorName":"孟国林","id":"b1cd7499-1163-4766-a6a0-6c3678556a2e","originalAuthorName":"孟国林"},{"authorName":"桑宏勋","id":"4765fe76-ec43-4867-b446-9012b257dfc2","originalAuthorName":"桑宏勋"}],"doi":"","fpage":"1984","id":"5c33af99-cbb4-4189-80c5-975a213c41b7","issue":"11","journal":{"abbrevTitle":"XYJSCLYGC","coverImgSrc":"journal/img/cover/XYJSCLYGC.jpg","id":"69","issnPpub":"1002-185X","publisherId":"XYJSCLYGC","title":"稀有金属材料与工程"},"keywords":[{"id":"e5b7e62d-60a9-4c45-9149-3e6ed1affc23","keyword":"多孔磷酸钙","originalKeyword":"多孔磷酸钙"},{"id":"138fd44c-d255-4bbb-a758-0a7c1e89785f","keyword":"钛合金","originalKeyword":"钛合金"},{"id":"88a42c5c-1862-492b-bcbe-ad6551c8524e","keyword":"多孔支架","originalKeyword":"多孔支架"},{"id":"39c22820-6f73-49ff-823d-754ee2342d59","keyword":"颅骨<span style=\"color:red\">缺损</span>","originalKeyword":"颅骨缺损"}],"language":"zh","publisherId":"xyjsclygc201011022","title":"多孔磷酸钙<span style=\"color:red\">骨</span>水泥与钛合金支架材料<span style=\"color:red\">修复</span>兔颅骨<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>的比较研究","volume":"39","year":"2010"},{"abstractinfo":"采用磷酸四钙和磷酸氢钙为磷灰石水泥(AC)粉末, 5wt%硅酸钠水溶液为固化液, 氯化钠为致孔剂, 制备了掺杂钠元素的硅磷灰石水泥(s-AC)多孔支架用于<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>再生<span style=\"color:red\">修复</span>. 结果显示: s-AC多孔支架的成分为含钠硅元素的磷灰石, 支架大孔之间互相贯通, 孔径在200~600 &mu;m, 孔隙率在58%~75%, 抗压强度在1.6~3.8MPa的范围内. 与AC相比, 掺杂一定量的钠硅元素提高了s-AC支架在Tris-HCl溶液中的降解性. 将s-AC多孔支架植入兔股骨<span style=\"color:red\">缺损</span>处, 组织学分析结果显示: 新生<span style=\"color:red\">骨</span>在支架材料的表面直接形成, 并长入其中, 相互贯通的多孔支架促进了新<span style=\"color:red\">骨</span>长入其内部. 结果表明: s-AC支架具有优良的生物相容性、降解性和成<span style=\"color:red\">骨</span>性, 将是一种优良的<span style=\"color:red\">骨</span><span style=\"color:red\">修复</span>生物材料.","authors":[{"authorName":"曹烈虎","id":"d9015e00-fd80-4c1c-b3a3-88e95dd7c51f","originalAuthorName":"曹烈虎"},{"authorName":"禹宝庆","id":"36eb8aad-1073-4199-a2f6-986e3ce09094","originalAuthorName":"禹宝庆"},{"authorName":"伍国胜","id":"4af1b0f4-c54e-46d1-933f-1ef0affc66b2","originalAuthorName":"伍国胜"},{"authorName":"苏佳灿","id":"2eb369c9-9a56-48c4-b493-239a9682cbd1","originalAuthorName":"苏佳灿"}],"categoryName":"|","doi":"10.3724/SP.J.1077.2011.00591","fpage":"591","id":"7f836471-c940-4690-94e2-8b39eebb7bff","issue":"6","journal":{"abbrevTitle":"WJCLXB","coverImgSrc":"journal/img/cover/WJCLXB.jpg","id":"62","issnPpub":"1000-324X","publisherId":"WJCLXB","title":"无机材料学报"},"keywords":[{"id":"7688f3a7-d5a8-4d4e-b18f-24951ae14e70","keyword":"钠硅磷灰石","originalKeyword":"钠硅磷灰石"},{"id":"89f2b319-fe17-43e4-9fc3-d60dea13c262","keyword":" cement porous scaffold","originalKeyword":" cement porous scaffold"},{"id":"a75e8071-86ef-4f23-893f-aacdd5b6af96","keyword":" biocompatibility","originalKeyword":" biocompatibility"},{"id":"94166c0b-3dbd-496c-bf79-4c1968a9679b","keyword":" degradation","originalKeyword":" degradation"},{"id":"236b1609-76ee-46eb-a6f6-59f80d4dbb66","keyword":" osteogenesis","originalKeyword":" osteogenesis"}],"language":"zh","publisherId":"1000-324X_2011_6_5","title":"掺杂钠硅磷灰石水泥多孔支架用于<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>再生<span style=\"color:red\">修复</span>","volume":"26","year":"2011"},{"abstractinfo":"采用磷酸四钙和磷酸氢钙为磷灰石水泥(AC)粉末,5wt%硅酸钠水溶液为固化液,氯化钠为致孔剂,制备了掺杂钠元素的硅磷灰石水泥(s-AC)多孔支架用于<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>再生<span style=\"color:red\">修复</span>.结果显示:s-AC多孔支架的成分为含钠硅元素的磷灰石,支架大孔之间互相贯通,孔径在200～600 μm,孔隙率在58%～75%,抗压强度在1.6～3.8MPa的范围内.与AC相比,掺杂一定量的钠硅元素提高了s-AC支架在Tris-HCl溶液中的降解性.将s-AC多孔支架植入兔股骨<span style=\"color:red\">缺损</span>处,组织学分析结果显示:新生<span style=\"color:red\">骨</span>在支架材料的表面直接形成,并长入其中,相互贯通的多孔支架促进了新<span style=\"color:red\">骨</span>长入其内部.结果表明:s-AC支架具有优良的生物相容性、降解性和成<span style=\"color:red\">骨</span>性,将是一种优良的<span style=\"color:red\">骨</span><span style=\"color:red\">修复</span>生物材料.","authors":[{"authorName":"曹烈虎","id":"4a43f597-4ef7-4038-a622-37b6c67deedf","originalAuthorName":"曹烈虎"},{"authorName":"禹宝庆","id":"44a35f7b-b987-49ae-9442-6e8a3072fe7b","originalAuthorName":"禹宝庆"},{"authorName":"伍国胜","id":"aa6a9b46-73d4-4cf3-994c-6a1498879532","originalAuthorName":"伍国胜"},{"authorName":"苏佳灿","id":"a89eeac4-de66-4d43-b2b2-f0691ad4e17b","originalAuthorName":"苏佳灿"}],"doi":"10.3724/SP.J.1077.2011.00591","fpage":"591","id":"2279a34c-9266-445b-bd16-d4f3b7564f02","issue":"6","journal":{"abbrevTitle":"WJCLXB","coverImgSrc":"journal/img/cover/WJCLXB.jpg","id":"62","issnPpub":"1000-324X","publisherId":"WJCLXB","title":"无机材料学报"},"keywords":[{"id":"429b039f-2e88-483d-8fee-bcb5becb6bfe","keyword":"钠硅磷灰石","originalKeyword":"钠硅磷灰石"},{"id":"536f601d-64c3-42ea-ba52-64489096bf40","keyword":"水泥多孔支架","originalKeyword":"水泥多孔支架"},{"id":"79696a7a-c8b5-4539-b135-5b4cd429bdd9","keyword":"生物相容性","originalKeyword":"生物相容性"},{"id":"e1e98212-2616-4c15-8d0b-56cc270bea9e","keyword":"降解","originalKeyword":"降解"},{"id":"c81c5275-ad08-46e8-8e52-255f5837b03f","keyword":"成<span style=\"color:red\">骨</span>","originalKeyword":"成骨"}],"language":"zh","publisherId":"wjclxb201106005","title":"掺杂钠硅磷灰石水泥多孔支架用于<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>再生<span style=\"color:red\">修复</span>","volume":"26","year":"2011"},{"abstractinfo":"目的构建<span style=\"color:red\">骨</span>形成蛋白2(Bone morphogenetic proteins2,BMP-2)基因修饰的β磷酸三钙(βtricalcium phosphate,β-TCP)/胶原复合支架材料,探讨其体内<span style=\"color:red\">修复</span>大鼠临界颅骨<span style=\"color:red\">缺损</span>的效果,评价其作为<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span><span style=\"color:red\">修复</span>材料的性能.方法 制备纳米级多孔3-TCP/胶原支架,并负载100μg BMP-2质粒DNA形成基因修饰的支架材料.将24只成年雄性SD大鼠随机分为BMP-2基因修饰的β-TCP/胶原支架组(n=8),3-TCP/胶原支架组(n=8),空白组(n=8).在大鼠颅骨顶部建立两个直径5mm的临界性<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>,植入材料后6周、12周取样本大体观察,组织学观察,免疫组织化学检测,并进行<span style=\"color:red\">骨</span>组织测量分析.结果 组织学观察可见12周时,材料已完全降解.BMP-2基因修饰支架组6周时,<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>区成<span style=\"color:red\">骨</span>活跃形成编织<span style=\"color:red\">骨</span>；12周时,<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>已基本愈合,新生<span style=\"color:red\">骨</span>组织逐渐成熟呈板层状,与宿主<span style=\"color:red\">骨</span>形成<span style=\"color:red\">骨</span>性连接.而单纯支架组6周时,<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>中心区为少量岛状<span style=\"color:red\">骨</span>组织；12周时,新生<span style=\"color:red\">骨</span>组织连接呈片状,<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>未完全愈合.免疫组化检测显示:6周和12周时,BMP-2基因修饰支架组中BMP-2表达均强于单纯支架组和空白组.<span style=\"color:red\">骨</span>组织形态计量分析显示BMP-2基因修饰支架组成骨质量和成<span style=\"color:red\">骨</span>效率明显高于单纯支架组和空白组(P＜0.05).结论 BMP 2基因修饰的β-TCP/胶原复合材料具有良好的生物相容性,<span style=\"color:red\">骨</span>诱导和<span style=\"color:red\">骨</span>传导性佳,是很有潜力的新型<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span><span style=\"color:red\">修复</span>材料.","authors":[{"authorName":"李娟","id":"67222fa0-acf8-4115-9149-9e801098ef9e","originalAuthorName":"李娟"},{"authorName":"郑闱颖","id":"edcb1ba7-cf13-4cd7-9d60-c847dd18c10d","originalAuthorName":"郑闱颖"},{"authorName":"卢岩","id":"657fb355-aefc-4b3d-b02a-cae33de42222","originalAuthorName":"卢岩"},{"authorName":"俞兰","id":"3eb60349-06b3-4c95-88bf-31c0ae6f37a0","originalAuthorName":"俞兰"},{"authorName":"林军","id":"1e03af9f-2d2a-4ef7-b705-1af02359480d","originalAuthorName":"林军"}],"doi":"","fpage":"248","id":"b4043794-f1d5-46d8-a69b-fd2625fa6b17","issue":"2","journal":{"abbrevTitle":"CLKXYGCXB","coverImgSrc":"journal/img/cover/CLKXYGCXB.jpg","id":"13","issnPpub":"1673-2812","publisherId":"CLKXYGCXB","title":"材料科学与工程学报"},"keywords":[{"id":"70760d25-f801-4618-962f-7b1af4c17283","keyword":"3磷酸三钙","originalKeyword":"3磷酸三钙"},{"id":"1e7bb31e-a78c-4815-aba3-07eb19c739e4","keyword":"胶原","originalKeyword":"胶原"},{"id":"48ede7db-8d69-4fb1-9949-a4316f03d1f1","keyword":"<span style=\"color:red\">骨</span>形成蛋白2","originalKeyword":"骨形成蛋白2"},{"id":"eff032cb-4033-4bda-80e0-68ad46f220f1","keyword":"质粒","originalKeyword":"质粒"},{"id":"37b7c83d-220e-4632-9f6b-ced4ed0af66f","keyword":"<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>","originalKeyword":"骨缺损"}],"language":"zh","publisherId":"clkxygc201302019","title":"<span style=\"color:red\">骨</span>形成蛋白-2基因修饰的β磷酸三钙/胶原复合材料<span style=\"color:red\">修复</span>颅骨<span style=\"color:red\">缺损</span>","volume":"31","year":"2013"},{"abstractinfo":"制备了PU/n-HA/PA66股<span style=\"color:red\">骨</span>髁,用扫描电镜观察材料表面情况并测定其孔隙率；将PU/n-HA/PA66股<span style=\"color:red\">骨</span>髁与自体髁植入犬股骨远端,以替代、<span style=\"color:red\">修复</span><span style=\"color:red\">骨</span>软骨<span style=\"color:red\">缺损</span>,进行大体观察、组织学、免疫组化、CT、血常规和生化检测以及肝、肾、脾组织学检测.结果表明材料孔隙率为80.89％±5.01％,孔径主要分布在300～800μm之间.术后实验动物活动正常,切口愈合良好,两组髁假体均与自体<span style=\"color:red\">骨</span>结合紧密,PU/n-HA/PA66股<span style=\"color:red\">骨</span>髁网孔中的<span style=\"color:red\">骨</span>小梁逐渐增多成熟,材料孔穴中的新生<span style=\"color:red\">骨</span>Ⅰ型胶原阳性表达.术后动物碱性磷酸酶水平升高[(62.67±24.04) U/L],肝、脾、肾HE染色未见异常.PU/n-HA/PA66股<span style=\"color:red\">骨</span>髁具有良好的<span style=\"color:red\">骨</span><span style=\"color:red\">修复</span>、软骨替代能力和生物相容性,具有应用前景.","authors":[{"authorName":"苏保","id":"bee53364-36e5-415f-b5c4-b6905c1325a8","originalAuthorName":"苏保"},{"authorName":"李吉东","id":"d6998a11-805e-4f04-8fd5-9a98fba69979","originalAuthorName":"李吉东"},{"authorName":"蒋电明","id":"bde3f921-743d-49fc-bccc-8bb002b38040","originalAuthorName":"蒋电明"},{"authorName":"李玉宝","id":"6a9d100f-849b-4b97-b71e-d8bae44ad667","originalAuthorName":"李玉宝"},{"authorName":"谯波","id":"b98959d3-a3fb-48b3-b075-2678807b36fe","originalAuthorName":"谯波"},{"authorName":"李维朝","id":"9f81a1c7-d8f5-4704-ae4b-c544f3f9814b","originalAuthorName":"李维朝"}],"doi":"","fpage":"493","id":"cc0d246d-6ac3-4726-bacf-b5be4599ccfe","issue":"4","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"5a43ef33-d468-451c-945b-48a54b22e74d","keyword":"<span style=\"color:red\">骨</span>软骨<span style=\"color:red\">缺损</span>","originalKeyword":"骨软骨缺损"},{"id":"ff995b22-1e0e-4cdb-8297-f7c31f60efdd","keyword":"聚氨酯","originalKeyword":"聚氨酯"},{"id":"ddd0027d-ef73-472d-b7ef-9dae81018b10","keyword":"纳米羟基磷灰石/聚酰胺66","originalKeyword":"纳米羟基磷灰石/聚酰胺66"},{"id":"8c68633c-1b6d-49ac-88e9-088046e382af","keyword":"股骨髁","originalKeyword":"股骨髁"},{"id":"00b7d178-8db5-4c6f-bed7-5320d0a7888f","keyword":"生物相容性","originalKeyword":"生物相容性"}],"language":"zh","publisherId":"gncl201304009","title":"聚氨酯/纳米羟基磷灰石/聚酰胺66股<span style=\"color:red\">骨</span>髁<span style=\"color:red\">修复</span>犬<span style=\"color:red\">骨</span>软骨<span style=\"color:red\">缺损</span>的实验研究","volume":"44","year":"2013"},{"abstractinfo":"论述了<span style=\"color:red\">骨</span><span style=\"color:red\">修复</span>机理和人工复合<span style=\"color:red\">骨</span><span style=\"color:red\">修复</span>材料的研究和发展状况,着重讨论了人工复合<span style=\"color:red\">骨</span><span style=\"color:red\">修复</span>材料的设计方向和应用前景.","authors":[{"authorName":"阮孜炜","id":"af9058e2-bc38-422c-9b3a-cb9d9596f24e","originalAuthorName":"阮孜炜"},{"authorName":"李东旭","id":"b2464622-f190-4ec8-8ce3-eb8febb726a2","originalAuthorName":"李东旭"}],"doi":"","fpage":"62","id":"09c1cac0-a879-41bd-a098-408133abe2b4","issue":"10","journal":{"abbrevTitle":"CLDB","coverImgSrc":"journal/img/cover/CLDB.jpg","id":"8","issnPpub":"1005-023X","publisherId":"CLDB","title":"材料导报"},"keywords":[{"id":"0f731055-8681-44b5-8294-4fa0add4c4d4","keyword":"<span style=\"color:red\">骨</span><span style=\"color:red\">修复</span>","originalKeyword":"骨修复"},{"id":"b536b6bd-6a51-4ca1-8c8c-fce20c16131d","keyword":"<span style=\"color:red\">骨</span>水泥","originalKeyword":"骨水泥"},{"id":"ace0a9fb-7854-4cfa-a787-c8cbb95cb937","keyword":"生物材料","originalKeyword":"生物材料"},{"id":"fb93c0ad-fef8-44b1-881e-0f4932cd1d54","keyword":"发展概况","originalKeyword":"发展概况"}],"language":"zh","publisherId":"cldb200310018","title":"人工复合<span style=\"color:red\">骨</span><span style=\"color:red\">修复</span>材料","volume":"17","year":"2003"},{"abstractinfo":"以特定的珊瑚为原料,制备出一种可吸收的多孔复合陶瓷--可吸收珊瑚羟基磷灰石(R-CHA).通过XRD、光镜和电镜等方法对材料进行观察分析.结果表明其主要成分是碳酸钙和羟基磷灰石,由羟基磷灰石薄层覆盖在碳酸钙骨架的表面,同时具有孔孔相通的三维结构.兔胫骨<span style=\"color:red\">缺损</span><span style=\"color:red\">修复</span>实验显示,该材料具有很好的生物相容性、<span style=\"color:red\">骨</span>传导性和成<span style=\"color:red\">骨</span>性,并可随新<span style=\"color:red\">骨</span>的生成在预计的时间内逐渐吸收.","authors":[{"authorName":"陈德夫","id":"5cf8669c-1c6c-4511-a8fd-cf013343331c","originalAuthorName":"陈德夫"},{"authorName":"宋正孝","id":"61d39e36-6da8-4b82-ae98-eaabeb72f75e","originalAuthorName":"宋正孝"},{"authorName":"范丽娟","id":"f89f0de3-d39b-4404-98de-63d3f0eec0bf","originalAuthorName":"范丽娟"},{"authorName":"袁宁","id":"0d9e1090-5f48-46f6-b339-2e682d220c93","originalAuthorName":"袁宁"},{"authorName":"田伟","id":"c4aaa283-a293-4d51-a135-f0b9c8d18072","originalAuthorName":"田伟"}],"doi":"","fpage":"2405","id":"944d7a4d-84d4-4426-8dac-dfd1c8702683","issue":"z1","journal":{"abbrevTitle":"GNCL","coverImgSrc":"journal/img/cover/GNCL.jpg","id":"33","issnPpub":"1001-9731","publisherId":"GNCL","title":"功能材料"},"keywords":[{"id":"ffc80ff6-8cbf-427a-a562-355d3cc1d853","keyword":"可吸收珊瑚羟基磷灰石","originalKeyword":"可吸收珊瑚羟基磷灰石"},{"id":"315596a8-6825-4eb9-ad1a-160cc1f39d6f","keyword":"制备","originalKeyword":"制备"},{"id":"2528f02a-c282-499f-a563-ad3c0e84dfc4","keyword":"<span style=\"color:red\">骨</span><span style=\"color:red\">缺损</span>","originalKeyword":"骨缺损"},{"id":"a0e01a66-bfa4-40a6-b3b0-b32e5e3d1cfd","keyword":"<span style=\"color:red\">修复</span>","originalKeyword":"修复"},{"id":"7ae1d082-3626-471f-9a31-9c92201ca652","keyword":"多孔陶瓷","originalKeyword":"多孔陶瓷"}],"language":"zh","publisherId":"gncl2004z1671","title":"可吸收珊瑚羟基磷灰石的制备及兔胫骨<span style=\"color:red\">缺损</span><span style=\"color:red\">修复</span>效果观察","volume":"35","year":"2004"}],"totalpage":170,"totalrecord":1698}