{"currentpage":1,"firstResult":0,"maxresult":10,"pagecode":5,"pageindex":{"endPagecode":5,"startPagecode":1},"records":[{"abstractinfo":"添加型阻燃剂多溴联苯醚(PBDEs)由于具有优异的阻燃性能,已被广泛应用于各种消费品中.PBDEs具有低水溶性,会强烈吸附有机物,导致PBDEs在环境介质和食物链中大量富积,对人类和动物都造成巨大危害.对多溴联苯醚生物降解、光降解和零价铁降解过程中的<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>和<span style=\"color:red\">代谢</span>过程中所需的酶进行综述,为多溴联苯醚的修复提供理论基础.","authors":[{"authorName":"才满","id":"2bb5b3d1-2b5b-4ee1-b4c9-16648a7ab113","originalAuthorName":"才满"},{"authorName":"杜克久","id":"b03642bf-e01b-4121-b03e-c7de665447da","originalAuthorName":"杜克久"}],"doi":"10.11896/j.issn.1005-023X.2016.011.016","fpage":"97","id":"c85f3c7c-8f5f-412b-bf4e-a49d22ceaa26","issue":"11","journal":{"abbrevTitle":"CLDB","coverImgSrc":"journal/img/cover/CLDB.jpg","id":"8","issnPpub":"1005-023X","publisherId":"CLDB","title":"材料导报"},"keywords":[{"id":"46dbe674-7399-4ea7-ab4e-f699886c2f18","keyword":"多溴联苯醚","originalKeyword":"多溴联苯醚"},{"id":"3e7f632a-663e-44ed-b051-fb4113c20202","keyword":"生物降解","originalKeyword":"生物降解"},{"id":"1917d892-072c-4c8b-868d-995118a66656","keyword":"光降解","originalKeyword":"光降解"},{"id":"3cfb66a1-143a-4e6e-9b63-40701794b826","keyword":"零价铁降解","originalKeyword":"零价铁降解"},{"id":"21fe78dc-efe9-4fe6-915c-e122f96818e9","keyword":"<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>","originalKeyword":"代谢途径"}],"language":"zh","publisherId":"cldb201611016","title":"多溴联苯醚降解的<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>","volume":"30","year":"2016"},{"abstractinfo":"产酸克雷伯氏菌(Klebsiella oxytoca)SG-11是从水稻根面分离的植物根际促生细菌, 具有生物固氮能力.利用HPLC和GC-MS对该菌的<span style=\"color:red\">代谢</span>产物进行了定性定量分析,结果表明该菌能产生较高浓度的吲哚-3-乙酸(IAA); 对其<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>的研究结果证明, 该菌以吲哚-3-丙酮酸<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>合成IAA.","authors":[{"authorName":"吕泽勋","id":"0b2fd796-a27a-4fe0-8b20-e0582b3eec51","originalAuthorName":"吕泽勋"},{"authorName":"宋未","id":"98d3942b-1929-427a-a5d8-bcf823e89b55","originalAuthorName":"宋未"}],"doi":"10.3321/j.issn:1000-8713.2000.04.012","fpage":"328","id":"6efe052a-250d-4ba4-98ae-a53969ecf945","issue":"4","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"0193ea96-4bfd-4ec8-8cb9-7215602517a2","keyword":"高效液相色谱法","originalKeyword":"高效液相色谱法"},{"id":"668d62f7-9afd-4690-8bfe-dcc978af3007","keyword":"质谱法","originalKeyword":"质谱法"},{"id":"c978797a-0e37-4920-a5b7-121d44033106","keyword":"产酸克雷伯氏菌SG-11","originalKeyword":"产酸克雷伯氏菌SG-11"},{"id":"46bb61aa-d82b-4d0e-8d74-fa45ef468e1c","keyword":"吲哚-3-乙酸","originalKeyword":"吲哚-3-乙酸"},{"id":"08e62ec2-3be9-48a4-9670-666d25f4bb47","keyword":"<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>","originalKeyword":"代谢途径"}],"language":"zh","publisherId":"sp200004012","title":"高效液相色谱和质谱法对产酸克雷伯氏菌SG-11生物合成吲哚-3-乙酸<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>的研究","volume":"18","year":"2000"},{"abstractinfo":"本文综述了目前动物模型中全氟羧酸类和全氟磺酸类前体物质的生物转化研究.绝大多数的<span style=\"color:red\">代谢</span>研究以大鼠和小鼠为对象,而以鱼为对象进行的研究相对较少.氟调聚丙烯酸酯类(8∶2 FTAc)和多氟烷基磷酸酯类(PAPs)均可先<span style=\"color:red\">代谢</span>为氟调聚醇类(FTOHs),最终<span style=\"color:red\">代谢</span>为全氟羧酸类(PFCAs).全氟磺酰胺类可最终<span style=\"color:red\">代谢</span>为全氟磺酸类(PFSAs).目前,以8∶2氟调聚醇(8∶2 FTOH)和N-乙酰全氟辛烷磺酰氨乙醇(N-EtFOSE)为主要研究物质,且工业中使用的全氟和多氟烷基物质碳链长度逐渐变短,所以有关短链物质的<span style=\"color:red\">代谢</span>研究也越来越多.","authors":[{"authorName":"崔永荟","id":"0835fff4-4cdc-4670-b7aa-a6febed35577","originalAuthorName":"崔永荟"},{"authorName":"高金芳","id":"db3c7050-2c1f-4d67-a10d-e22b59ca5ec0","originalAuthorName":"高金芳"},{"authorName":"陶燕飞","id":"d9f2bce9-c832-441a-91d5-692326da6197","originalAuthorName":"陶燕飞"},{"authorName":"王玉莲","id":"2fcc02f0-10a8-459c-8a90-0b3fced24726","originalAuthorName":"王玉莲"},{"authorName":"彭大鹏","id":"5a292b9f-5917-4d6d-9fe7-9682196ddd5d","originalAuthorName":"彭大鹏"},{"authorName":"袁宗辉","id":"87aae636-1f7d-4fe9-921d-a92e0cd6973d","originalAuthorName":"袁宗辉"},{"authorName":"陈冬梅","id":"488705f1-5893-425f-80a8-35a6d56c70f3","originalAuthorName":"陈冬梅"}],"doi":"10.7524/j.issn.0254-6108.2016.10.2016031501","fpage":"1994","id":"53ad20c8-ce81-4719-aba4-4a90e98b295c","issue":"10","journal":{"abbrevTitle":"HJHX","coverImgSrc":"journal/img/cover/HJHX.jpg","id":"43","issnPpub":"0254-6108","publisherId":"HJHX","title":"环境化学   "},"keywords":[{"id":"d1284b01-20b4-46d2-8ec5-b282e3dff6b6","keyword":"全氟和多氟烷基物质","originalKeyword":"全氟和多氟烷基物质"},{"id":"1a46513e-2238-41bc-b6ce-5b00cb98fbf7","keyword":"<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>","originalKeyword":"代谢途径"},{"id":"3aff35bf-c49b-4593-9bcc-7188f52e6e57","keyword":"<span style=\"color:red\">代谢</span>机制","originalKeyword":"代谢机制"},{"id":"285765bd-0abe-46d5-86c9-cd7c73d9d7fc","keyword":"动物","originalKeyword":"动物"}],"language":"zh","publisherId":"hjhx201610003","title":"全氟和多氟烷基物质在动物中的<span style=\"color:red\">代谢</span>研究进展","volume":"35","year":"2016"},{"abstractinfo":"建立了基于超高效液相色谱-飞行时间质谱(UPLC/TOF MS)分析技术的血浆<span style=\"color:red\">代谢</span>指纹谱,应用多元统计分析方法评价糖尿病肾病患者血浆<span style=\"color:red\">代谢</span>物变化差异及糖肾方的干预效果.通过研究糖肾方干预糖尿病肾病血浆内源性<span style=\"color:red\">代谢</span>物的变化,探索与该疾病密切相关的<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>,评价糖肾方的治疗效果.结果发现:经糖肾方治疗后,血浆内源性<span style=\"color:red\">代谢</span>物发生了明显变化,磷脂<span style=\"color:red\">代谢</span>、脂肪酸<span style=\"color:red\">代谢</span>、氨基酸<span style=\"color:red\">代谢</span>、嘌呤嘧啶<span style=\"color:red\">代谢</span>、固醇类<span style=\"color:red\">代谢</span>等多个<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>得到纠正.本研究基于UPLC/TOF MS的<span style=\"color:red\">代谢</span>组学方法,能够从整体水平反映疾病治疗过程中<span style=\"color:red\">代谢</span>网络的变化趋势,证实糖肾方具有治疗糖尿病肾病的临床疗效并有助于阐释药物作用机理.","authors":[{"authorName":"于欢","id":"7afa4f93-d99e-4c94-9ae9-a32d475b6c8b","originalAuthorName":"于欢"},{"authorName":"黎莉","id":"85a600fd-801d-4b39-a3b7-2e9ec55bc294","originalAuthorName":"黎莉"},{"authorName":"梁琼麟","id":"0e61fe15-fd98-406e-892f-5aede3c1a07a","originalAuthorName":"梁琼麟"},{"authorName":"王义明","id":"fb13cc58-f99b-4028-8e05-ad395e216123","originalAuthorName":"王义明"},{"authorName":"李平","id":"54a92b83-55d2-4e7f-99ad-9f9b173e5403","originalAuthorName":"李平"},{"authorName":"罗国安","id":"f3c76932-2817-4111-b75c-7bf0fbb9c9fa","originalAuthorName":"罗国安"}],"doi":"10.3724/SP.J.1123.2011.00320","fpage":"320","id":"09238177-adea-4237-b5eb-0f71873b84ff","issue":"4","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"30249430-791e-4a3b-815c-c5432001ece6","keyword":"超高效液相色谱-飞行时间质谱","originalKeyword":"超高效液相色谱-飞行时间质谱"},{"id":"0c4a0835-f604-462b-af94-9ab8172e993e","keyword":"<span style=\"color:red\">代谢</span>组学","originalKeyword":"代谢组学"},{"id":"a71f9aac-e431-4e27-ae99-593f55551a3e","keyword":"糖肾方","originalKeyword":"糖肾方"},{"id":"ce2dfbbb-3a51-496c-b4b2-a4fcb635cecf","keyword":"糖尿病肾病","originalKeyword":"糖尿病肾病"}],"language":"zh","publisherId":"sp201104008","title":"<span style=\"color:red\">代谢</span>组学应用于糖肾方治疗糖尿病肾病的疗效评价","volume":"29","year":"2011"},{"abstractinfo":"拥有一个强势的品牌是现在每一个企业都在努力追求的目标,已有的品牌应当怎样强化它在消费者心目中的地位呢?本文通过对品牌强化的三条<span style=\"color:red\">途径</span>的分析,指出了维护品牌资产的三种方法,希望对品牌管理者有所裨益.","authors":[{"authorName":"王炳成","id":"fd2a5836-dca5-4e29-9321-387de3d08662","originalAuthorName":"王炳成"}],"doi":"10.3969/j.issn.1000-6826.2006.03.018","fpage":"52","id":"0bf0f871-8634-438a-b2f3-b5849c1e4cb4","issue":"3","journal":{"abbrevTitle":"JSSJ","coverImgSrc":"journal/img/cover/3abe017a-2574-4821-8152-4ae974ef0471.jpg","id":"47","issnPpub":"1000-6826","publisherId":"JSSJ","title":"金属世界"},"keywords":[{"id":"14efa0b6-32f4-41fe-8b84-47580ba021e0","keyword":"品牌","originalKeyword":"品牌"},{"id":"66c6aa50-f9ad-48ef-9f23-64d1e7d6fedb","keyword":"品牌强化","originalKeyword":"品牌强化"}],"language":"zh","publisherId":"jssj200603018","title":"品牌强化的<span style=\"color:red\">途径</span>","volume":"","year":"2006"},{"abstractinfo":"采用弗氏完全佐剂（ FCA）诱导佐剂性关节炎（ AA）大鼠模型，观察大鼠足趾肿胀度和踝关节组织的病理学形态变化。应用气相色谱-飞行时间质谱（ GC-TOF MS）技术检测 AA 大鼠尿液<span style=\"color:red\">代谢</span>物谱，并对数据进行主成分分析（ PCA）、偏最小二乘法-判别分析（ PLS-DA）及正交偏最小二乘法-判别分析（ OPLS-DA），探讨可能的发病机制。通过变量重要性投影值（ VIP ﹥1）和 P值（﹤0.05），筛选出尿液中的差异<span style=\"color:red\">代谢</span>物。在模型组大鼠的尿液中共发现异柠檬酸、α-酮戊二酸、柠康酸、肌酸、3-羟基丁酸等20种差异<span style=\"color:red\">代谢</span>物。推断 AA<span style=\"color:red\">代谢</span>组学的发病机制可能与能量<span style=\"color:red\">代谢</span>、氨基酸<span style=\"color:red\">代谢</span>、脂肪酸<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>有关。","authors":[{"authorName":"汪永忠","id":"9987de26-40fe-4c97-9c49-b65fdb72a768","originalAuthorName":"汪永忠"},{"authorName":"柳清","id":"c0b600af-e538-4ee7-9c1b-8a4e208117ec","originalAuthorName":"柳清"},{"authorName":"姜辉","id":"e3c01896-1a28-40cf-b4e0-e6cb882e49c3","originalAuthorName":"姜辉"},{"authorName":"韩燕全","id":"156f9c2a-8960-487c-8572-c095fcdcbc37","originalAuthorName":"韩燕全"},{"authorName":"李钰馨","id":"cf311259-221e-490e-b986-878f6abbe974","originalAuthorName":"李钰馨"}],"doi":"10.3724/SP.J.1123.2016.01020","fpage":"602","id":"905aa012-a5f9-442d-9b8d-6216030bf7e5","issue":"6","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"ca4fa9c4-7d7a-4803-b76e-bb700ae8a4f1","keyword":"气相色谱-飞行时间质谱","originalKeyword":"气相色谱-飞行时间质谱"},{"id":"549d1b85-3ea7-448b-9b80-b4ce26289857","keyword":"佐剂性关节炎","originalKeyword":"佐剂性关节炎"},{"id":"c0af07e2-b8e6-4223-b4ec-d659ac6bb697","keyword":"<span style=\"color:red\">代谢</span>组学","originalKeyword":"代谢组学"},{"id":"68735cc0-c7db-485f-af39-95c126b896b1","keyword":"尿液","originalKeyword":"尿液"}],"language":"zh","publisherId":"sp201606010","title":"基于气相色谱-飞行时间质谱技术的佐剂性关节炎大鼠尿液<span style=\"color:red\">代谢</span>组学的研究","volume":"34","year":"2016"},{"abstractinfo":"肿瘤<span style=\"color:red\">代谢</span>在最近几年重新获得重视,讨论肿瘤<span style=\"color:red\">代谢</span>我们无法避开瓦伯格效应,尽管瓦伯格效应在20世纪20年代就提出来了.瓦伯格效应也称需氧糖酵解,是指在有氧的条件下癌细胞过量摄取葡萄糖,产生更多的乳酸.此外,癌细胞也可摄取其他物质,如谷氨酰胺、丝氨酸和甘氨酸等作为能量需求与营养来源.为了描述癌细胞中改变了的<span style=\"color:red\">代谢</span>通路,同位素标记示踪技术提供了一种新的全局观点,让我们更好地理解在癌基因或抑癌基因调控下的<span style=\"color:red\">代谢</span>切换.色谱与质谱联用是一种重要的分析工具,可定量检测带有同位素标记的<span style=\"color:red\">代谢</span>物,从而剖析肿瘤细胞中的生物化学反应.在本文中,我们总结了基于质谱的肿瘤<span style=\"color:red\">代谢</span>分析的研究概况并提出未来的研究方向.重点讨论碳-13标记与氘代标记的示踪技术分析中间<span style=\"color:red\">代谢</span>产物,包括还原型烟酰胺腺嘌呤二核苷酸磷酸(NADPH).目前生物化学教科书中认为NADPH主要来源于磷酸戊糖<span style=\"color:red\">途径</span>.然而,氘代示踪技术分析表明,包括一碳<span style=\"color:red\">代谢</span>在内的其他<span style=\"color:red\">代谢</span>通路对产生NADPH也很重要.以上内容都在本文中进行了讨论.","authors":[{"authorName":"林树海","id":"8e06c99e-043f-4e5a-af5b-fbdd2846b0c5","originalAuthorName":"林树海"},{"authorName":"蔡宗苇","id":"2946c00f-fdae-4a41-b5ba-dd2646fead1c","originalAuthorName":"蔡宗苇"}],"doi":"10.3724/SP.J.1123.2014.11011","fpage":"112","id":"935508d4-d365-433f-9292-f64d4051014f","issue":"2","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"7327419b-1278-4e40-a2de-4bba3fbc46a7","keyword":"<span style=\"color:red\">代谢</span>流分析","originalKeyword":"代谢流分析"},{"id":"72fc2aa2-68af-424f-ae08-415dc49c32c0","keyword":"同位素示踪","originalKeyword":"同位素示踪"},{"id":"0fe0117f-84b9-417c-81ba-4ea72391baca","keyword":"细胞<span style=\"color:red\">代谢</span>","originalKeyword":"细胞代谢"},{"id":"a687d32a-7a00-4b8b-9e2d-f99b45514bad","keyword":"质谱","originalKeyword":"质谱"},{"id":"79e8397f-b21c-49d3-9168-c910ed1edeb7","keyword":"综述","originalKeyword":"综述"}],"language":"zh","publisherId":"sp201502002","title":"同位素示踪技术定量分析肿瘤细胞中的<span style=\"color:red\">代谢</span>重编","volume":"33","year":"2015"},{"abstractinfo":"采用超高效液相色谱-四极杆-飞行时间质谱（ UPLC／Q-TOF MS）检测和鉴定了猪尿中氯丙那林的主要<span style=\"color:red\">代谢</span>产物，并讨论了氯丙那林在猪体内的主要<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>。按10 mg／kg（ b． w．）的剂量口服灌食氯丙那林，分别采集给药前及给药后的猪尿液样品。采用 UPLC／Q-TOF MS对样品进行分析，并应用质量亏损过滤和离子色谱峰提取等数据处理技术，在给药后24 h内的猪尿中检测和鉴定了9种氯丙那林的<span style=\"color:red\">代谢</span>产物，其中，Ⅰ相<span style=\"color:red\">代谢</span>产物2种，Ⅱ相<span style=\"color:red\">代谢</span>产物7种。然后，根据氯丙那林原形和<span style=\"color:red\">代谢</span>产物的碎片离子特征，对<span style=\"color:red\">代谢</span>产物的结构进行鉴定。最后，根据所鉴定的<span style=\"color:red\">代谢</span>产物，推测氯丙那林在猪体内的<span style=\"color:red\">代谢</span><span style=\"color:red\">途径</span>包括苯环羟基化、β-羟基和仲氨基的葡萄糖醛酸轭合、羟基化后的葡萄糖醛酸和硫酸轭合等。研究结果表明，羟基化氯丙那林及其轭合产物的相对含量大于60％，明显高于氯丙那林原形及其轭合产物，是尿液中的主要<span style=\"color:red\">代谢</span>产物。本研究将为确定氯丙那林在动物体内的残留标示物及加强对氯丙那林非法使用的监控提供科学依据。","authors":[{"authorName":"毕言锋","id":"61d5fa25-33fb-4ea6-b1d7-d6bbd5b9cb71","originalAuthorName":"毕言锋"},{"authorName":"王亦琳","id":"241b359a-62f0-48ef-aa39-ff5f6fa881f9","originalAuthorName":"王亦琳"},{"authorName":"叶妮","id":"8653feb6-2dfe-4cd8-8bea-43fdac5587f0","originalAuthorName":"叶妮"},{"authorName":"孙雷","id":"2e992536-31bd-4687-a26e-451d26edf063","originalAuthorName":"孙雷"},{"authorName":"王鹤佳","id":"b1244c73-d17d-439f-98d0-48800f850e3f","originalAuthorName":"王鹤佳"},{"authorName":"徐士新","id":"b18b4555-db26-4266-8b12-25350627ac45","originalAuthorName":"徐士新"},{"authorName":"肖希龙","id":"9c5bf5cd-a992-44ec-958d-a4879e7b74d9","originalAuthorName":"肖希龙"}],"doi":"10.3724/SP.J.1123.2015.03007","fpage":"704","id":"7364c836-70fc-4ad7-b1d3-ec54b303d673","issue":"7","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"3c51d395-a079-4e36-a21a-5aa842f25606","keyword":"超高效液相色谱-四极杆-飞行时间质谱","originalKeyword":"超高效液相色谱-四极杆-飞行时间质谱"},{"id":"945cf241-4e22-43b1-b9c8-1db1402018d4","keyword":"氯丙那林","originalKeyword":"氯丙那林"},{"id":"f2e91ca8-72e1-42f3-a86a-85a7ec24463a","keyword":"<span style=\"color:red\">代谢</span>产物","originalKeyword":"代谢产物"},{"id":"44283c4b-d9b7-4729-b51d-4d45c6b4816c","keyword":"猪尿","originalKeyword":"猪尿"}],"language":"zh","publisherId":"sp201507006","title":"超高效液相色谱-四极杆-飞行时间质谱检测和鉴定猪尿中氯丙那林的主要<span style=\"color:red\">代谢</span>产物","volume":"","year":"2015"},{"abstractinfo":"电镀工业是不可缺少的基础工业,但电镀也带来环境的污染,因而其发展受到限制.对电镀生产存在的问题进行了论述,并提出建立清洁生产的<span style=\"color:red\">途径</span>,如采用对生产全过程的控制;采用无毒或低毒工艺;逆流清洗;优化工艺;加强废物处理和管理等,以解决和改善电镀工业对环境的危害.","authors":[{"authorName":"屠振密","id":"67ce54a8-2048-4c8a-ada4-9e9f07881e83","originalAuthorName":"屠振密"},{"authorName":"李宁","id":"85251a4d-d61a-424d-8b2e-6eeae749c111","originalAuthorName":"李宁"},{"authorName":"于元春","id":"76a66e6f-b7b5-4f29-8bf0-7d1bc6db5219","originalAuthorName":"于元春"}],"doi":"10.3969/j.issn.1001-3849.2005.05.008","fpage":"30","id":"6c561813-297f-4845-aa16-bd198704c111","issue":"5","journal":{"abbrevTitle":"DDYJS","coverImgSrc":"journal/img/cover/DDYJS.jpg","id":"20","issnPpub":"1001-3849","publisherId":"DDYJS","title":"电镀与精饰   "},"keywords":[{"id":"acf6561b-fdf0-477b-95bf-3ff7cc502f2c","keyword":"电镀","originalKeyword":"电镀"},{"id":"0b51678d-80ca-42ef-9a94-d7376e0e355e","keyword":"清洁生产","originalKeyword":"清洁生产"},{"id":"c647e3f1-2370-4ce3-aa09-4678551c5cb3","keyword":"污染防治","originalKeyword":"污染防治"},{"id":"90589661-52a9-4f5a-91ca-ff8aeb5fbbf9","keyword":"环境保护","originalKeyword":"环境保护"}],"language":"zh","publisherId":"ddjs200505008","title":"电镀清洁生产的<span style=\"color:red\">途径</span>","volume":"27","year":"2005"},{"abstractinfo":"基于液相色谱-质谱联用的<span style=\"color:red\">代谢</span>组学技术因其高效分离能力和高灵敏检测能力已成为生命科学研究的重要手段，但由于缺乏有效的通用标准谱图库，检测到的大量<span style=\"color:red\">代谢</span>物的结构难以鉴定。这制约了<span style=\"color:red\">代谢</span>组学覆盖度的提高和生物标志物的发现，造成化学和生物信息的严重丢失，成为<span style=\"color:red\">代谢</span>组学发展的主要技术瓶颈。随着质谱仪器及计算机技术的进步，基于大气压电离质谱（ API-MS）的<span style=\"color:red\">代谢</span>物结构鉴定技术飞速发展，本文从质谱仪器、<span style=\"color:red\">代谢</span>物分子结构式判别、数据库及谱图检索以及计算机辅助谱图解析等方面，对<span style=\"color:red\">代谢</span>物结构鉴定的最新进展进行了综述。","authors":[{"authorName":"孔宏伟","id":"a2b7ad1a-b788-408a-9388-7235fa2b99cd","originalAuthorName":"孔宏伟"},{"authorName":"戴伟东","id":"0b366ee5-fbf7-4265-923c-d33f2c0de1d6","originalAuthorName":"戴伟东"},{"authorName":"许国旺","id":"62ae696d-782d-4349-8a7a-9779c04acf8d","originalAuthorName":"许国旺"}],"doi":"10.3724/SP.J.1123.2014.05017","fpage":"1052","id":"d5aac405-f0fb-4466-b058-f30035b3de3b","issue":"10","journal":{"abbrevTitle":"SP","coverImgSrc":"journal/img/cover/SP.jpg","id":"58","issnPpub":"1000-8713","publisherId":"SP","title":"色谱 "},"keywords":[{"id":"c82e7328-e6a4-4a9b-9ed2-89a29fdcbdf0","keyword":"<span style=\"color:red\">代谢</span>组学","originalKeyword":"代谢组学"},{"id":"30f4f93e-762b-4e3e-96d0-91aca0624bf8","keyword":"液相色谱-质谱联用","originalKeyword":"液相色谱-质谱联用"},{"id":"955bf766-c0f7-4f9f-b21a-bc13ddcaf3c8","keyword":"大气压电离质谱","originalKeyword":"大气压电离质谱"},{"id":"83cba37d-45a1-42fa-9159-6a4d058ac728","keyword":"鉴定","originalKeyword":"鉴定"},{"id":"8ccd3378-063d-46a1-8d37-a0cd1d227f19","keyword":"综述","originalKeyword":"综述"}],"language":"zh","publisherId":"sp201410007","title":"基于液相色谱-质谱联用的<span style=\"color:red\">代谢</span>组学研究中<span style=\"color:red\">代谢</span>物的结构鉴定进展","volume":"","year":"2014"}],"totalpage":301,"totalrecord":3008}